Giuseppe Costante - EMA

Curriculum vitae
PERSONAL INFORMATION
Giuseppe Costante
WORK EXPERIENCE
March 1985–November 1990
Attending physician
University of Messina (Italy)
clinical activity in Internal Medicine and research in thyroid pathophysiology
January 1991–June 2000
Research Associate
University of Catanzaro (Italy)
Clinical and basic research in thyroid pathophysiology
June 2000–June 2012
Assistant Professor in Endocrinology
University of Catanzaro (Italy)
Teaching, clinical activity as Assistant Head Physician in Endocrinology, clinical research in thyroid
cancer
July 2012–Present
Head of the Endocrinology Clinic
Instiut Jules Bordet, Comprehensive Cancer Center (Belgium)
Clinical activity in the management of endocrine cancers, namely advanced thyroid thyroid cancers.
Research projects under developement.
October 2015–Present
Senior Lecturer, School of Medicine
Free University of Brussels (Belgium)
Theaching, Internal Medicine and Endocrinology
EDUCATION AND TRAINING
November 1973–July 1979
Medical student
University of Messina (Italy)
graduation as MD, magna cum laude
November 1979–November 1984
Post-graduate student
Post-graduate School in Endocrinology, University of Catania (Italy)
Training in Endocrinology, Specialist-PhD in Endocrinology, Magna cum laude
January 1982–February 1985
Research fellow
Université Libre de Bruxelles (Belgium)
Basic research in thyroid pathophysiology - Transport and peripheral effects of thyroid hormones
June 1992–March 1994
Visiting Scientist
University of California - San Francisco - Ca (United States)
Basic research in thyroid autoimmunity - molecular immunology -characterization of antithyroperoxidase auto-antibodies
ADDITIONAL INFORMATION
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Curriculum vitae
Expertise
Giuseppe Costante
European Medicines Agency - Clinical Expert on behalf of the Federal Agency for Medicines and
Health Products, Belgium
Endocrinology
Oncology
Thyroid cancer
Publications
1. DE LUCA F., TRIMARCHI F., SFERLAZZAS C., BENVENGA S., COSTANTE G., MAMI' C., DI
PASQUALE G., MAGAZZU' G.
Thyroid function in children with cystic fibrosis.
Eur. J. Ped. 138 : 327, 1982.
2. BENVENGA S., COSTANTE G., MELLUSO R., LUZZA G., PUSTORINO S., TURIANO S.,
TRIMARCHI F.
Failure to find evidence of immunoglobulin inhibitor(s) of thyroid hormone binding protein in nonthyroid illnesses.
Acta Endocrinologica 103 : 46, 1983
3. TRIMARCHI F., BENVENGA S., COSTANTE G., BARBERA C., MELLUSO R., MARCOCCI C.,
CHIOVATO L., DE LUCA F., CONSOLO F.
Identification and characterization of circulating thyroid.hormone binding auto-antibodies in thyroid
disease, in autoimmune non thyroid illnesses and lymphoreticular system disorders.
J. Endocrinol. Invest. 6 : 203, 1983.
4. BENVENGA S., TRIMARCHI F., BARBERA C., COSTANTE G., MORABITO S., BARBERIO G.,
CONSOLO F.
Circulating immunoglobulin E (IgE) antibodies to l-thyroxine in a euthyroid patient with multinodular
goiter and allergic rhinitis.
J. Endocrinol. Invest. 7 : 47, 1984.
5. COSTANTE G., SAND G., REDING P., GLINOER D.
Absence of circulating desialylated thyroxine-binding globulin in patients with hepatobiliary disease.
Acta Endocrinologica 108 : 392, 1985.
6. BENVENGA S., VERMIGLIO F., SOBBRIO G.A., COSTANTE G.,
TRIMARCHI F.
Studies on the interference of circulating immunoglobulins to thyroxine on thyroxine-binding globulin
immunoradiometric assay.
LAB, J. Res. Lab. Med. 12 : 203, 1985.
7. COSTANTE G., SAND G., CONNART D., GLINOER D.
In vitro effects of thyroid hormones on red blood cell Ca2+-dependent ATPase activity.
J. Endocrinol. Invest. 9 : 15, 1986.
8. ENIA G., COSTANTE G., CATALANO C., ZOCCALI C., MAGGIORE Q.
Severe hypothyroidism induced by amiodarone in a dialysis patient.
Nephron 46 : 206, 1987.
9. COSTANTE G., DEMEESTER-MIRKINE N., CRUPI D., TRIMARCHI F.
Hypothyroidism induced by pregnancy in a patient submitted to suppressive l-thyroxine treatment.
J. Endocrinol. Invest. 10 : 527, 1987.
10. ENIA G., CATALANO C., ZOCCALI C., MAGGIORE Q. COSTANTE G.,
Amiodarone.
N. Engl. J. Med. 317: 452, 1987
11. COSTANTE G., CRUPI D., CATALFAMO R., TRIMARCHI F.
Stimulation of liver mitochondrial alpha-glycerophosphate dehydrogenase activity by l-thyroxine in
thyroidectomized rats: comparison with the suppression of pituitary TSH secretion.
J. Endocrinol Invest. 13 : 61, 1990
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Curriculum vitae
Giuseppe Costante
12. COSTANTE G., CRUPI D., CATALFAMO R., TRIMARCHI F.
Effects of active immunization against l-triiodothyronine on serum thyrotropin and liver alphaglycerophospate dehydrogenase activity in rats: evidence for reduced hormone disposal to cells.
J. Endocrinol. Invest. 13 : 469, 1990.
13. FOTI D., CATALFAMO R., RUSSO D., COSTANTE G., FILETTI S.
Lack of relationship between 3',5' cyclic adenosine monophosphate desensitization and thyrotropin
receptor down regulation in the rat thyroid cell line FRTL5.
J. Endocrinol. Invest. 14: 213, 1991.
14. FILETTI S. , FOTI D., COSTANTE G., RAPOPORT B.
Recombinant human thyrotropin receptor in a radioreceptor assay for the measurement of TSH
receptor autoantibodies.
J. Clin. Endocrinol. Metab. 72: 1096-1101, 1991.
15. FOTI D., RUSSO D., COSTANTE G., FILETTI S.
The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of
human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin.
J. Clin. Endocrinol. Metab. 73: 710-716, 1991.
16. CHAZENBALK G. D., COSTANTE G., PORTOLANO S., McLACHLAN S. M., RAPOPORT B.
The immunodominant region on human thyroid peroxidase recognized by autoantibodies does not
contain the monoclonal antibody 47/c21 linear epitope.
J. Clin. Endocrionol. Metab. 77: 1715-1718, 1993.
17. NISHIKAWA T., COSTANTE G., PRUMMEL M. F., McLACHLAN S. M., RAPOPORT B.
Recombinant thyroid peroxidase autoantibodies can be used for epitopic “fingerprinting” of thyroid
peroxidase autoantibodies in the sera of individual patients.
J. Clin. Endocrinol. Metab. 78: 944-946, 1994.
18. JAUME J. C., COSTANTE G., PORTOLANO S., McLACHLAN S. M., RAPOPORT B.
Recombinant thyroid peroxidase autoantibodies: I. How diverse is the pool of heavy and light chains in
immunoglobulin gene libraries constructed from thyroid tissue infiltrating plasma cells?
Endocrinology 135: 16-24, 1994.
19. COSTANTE G., PORTOLANO S., NISHIKAWA T., JAUME J. C., CHAZENBALK G. D.,
RAPOPORT B., McLACLAN S. M.
Recombinant thyroid specific autoantibodies: II. Role of individual heavy and light chains in
determining epitope recognition.
Endocrinology 135: 25-30, 1994.
20. PRUMMEL M. F., PORTOLANO S., COSTANTE G., RAPOPORT B., McLACHLAN S. M.
Isolation and characterization of a Monoclonal human thyroid peroxidase autoantibody of lambda
chain type.
Mol. Cell. Endocrinol. 102: 161-166, 1994.
21. RUSSO D., DAMANTE G., FOTI D., COSTANTE G., FILETTI S.
Different molecular mechanisms are involved in the multihormonal control of glucose transport in
FRTL-5 rat thyroid cells.
J.Endocrinol.Invest. 17: 323-327, 1994.
22. JAUME J.C*., COSTANTE G*., NISHIKAWA T. , PHILLIPS D. I. W., RAPOPORT B.,
McLACHLAN S. M.
Thyroid peroxidase autoantibody fingerprints: I. A cross sectional study in elderly women.
J. Clin. Endocrinol. Metab. 80:994-999, 1995.
* equal contribution
23. JAUME J. C., PARKES A.B., LAZARUS J.H., HALL R., COSTANTE G., McLACHLAN S.M.,
RAPOPORT B.
Thyroid peroxidase autoantibody fingerprints: II. A longitudinal study in post-partum thyroiditis.
J. Clin. Endocrinol. Metab. 80: 1000-1005, 1995.
24. GUO J., QUARANTINO S., JAUME J. C., COSTANTE G., LONDEI M., McLACHLAN S.,
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RAPOPORT B.
Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fc epsilon receptor
by an autoantibody Fab converted to IgE.
J. Immunol. Methods 195: 81-92, 1996.
25. COSTANTE G., GRASSO L., LUDOVICO O., MARASCO M.F., NOCERA M., SCHIFINO E.,
RIVALTA L., CAPULA C., CHIARELLA R., FILETTI S., PARLATO G.
The statistical analysis of neonatal TSH results from congenital hypothyroidism screening programs
provides a useful tool for the characterization of moderate iodine deficiency regions.
J. Endocrinol. Invest. 20: 251-256-1997.
26. RUSSO D., WONG M.G., COSTANTE G., CHIEFARI E., TRESELER P.A., ARTURIF., FILETTI
S., CLARK O.
A Val677 activating mutation of the thyrotropin receptor in a Hürtle cell thyroid carcinoma associated
with thyrotoxicosis.
Thyroid 9: 13-17, 1999
27. COSTANTE G., GRASSO L., SCHIFINO E., MARASCO M.F., CROCETTI U., CAPULA C.,
CHIARELLA R., LUDOVICO O., NOCERA M., PARLATO G., FILETTI S.
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of
iodine status regionwide.
J. Endocrinol. Invest. 25: 201-207, 2002.
28. COSTANTE G., CROCETTI U., SCHIFINO E., LUDOVICO O., CAPULA C., NICOTERA M:,
ARTURI F., FILETTI
Slow growth of benign thyroid nodules after menopause: no need for long term thyroxine suppressive
therapy in post-menopausal women.
J. Endocrinol Invest. 27: 31-37, 2004.
29. TORLONTANO M., ATTARD M., CROCETTI U., TUMINO S., BRUNO R., COSTANTE G.,
D’AZZÒ G., MERINGOLO D., FERRETTI E., SACCO R, ARTURI F., FILETTI S.
Follow-up of low-risk patients with papillary thyroid cancer: role of neck ultrasonography in detecting
lymph node metastases
J. Clin. Endocrinol. Metab. 89: 3402-3407, doi:10.1210/jc.2003-031521 , 2004
30. BRUNO R., GIANNASIO P., BELLITTI P., SINISI R., ARTURI F., RUSSO D., COSTANTE G.
Lack of TSH inhibition by exogenous L-thyroxine in a patient with follicular thyroid carcinoma.
J. Endocrinol. Invest. 28: 663-666, 2005
31. COSTANTE G., MERINGOLO D., DURANTE C., BIANCHI D., NOCERA M., TUMINO S.,
CROCETTI U., ATTARD M., MARANGHI M., TORLONTANO M., FILETTI S.
Predictive value of serum Calcitonin levels for preoperative diagnosis of Medullary Thyroid Carcinoma
in a cohort of 5817 consecutive patients with thyroid nodules.
J. Clin. Endocrinol. Metab. 92: 450–455, doi: 10.1210/jc.2006-1590, 2007
32. SCIPIONI A., FERRETTI E., SODA G., TOSI E., BRUNO R., COSTANTE G., MERINGOLO D.,
ARTURI F., DURANTE C., AMOROSI A., FOSCHINI M. P., NARDI F., RUSSO D., FILETTI S.
hNIS protein in thyroid: the iodine supply influences its expression and localization.
Thyroid 17: 613-618, 2007.
33. MORISI R , CELANO M., TOSI E., SCHENONE S., NAVARRA M., FERRETTI E., COSTANTE
G., DURANTE C., BOTTA G., D’AGOSTINO M., BRULLO C., FILETTI S, BOTTA M., RUSSO D.
Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivate
J. Endocrinol. Invest. 30: RC31-4, 2007
34. LABONIA AF., CARNOVALE SCALZO G., PAOLA; A. , SCORCIA V., DE MORELLI G.;
BRUZZICHESSI D., SCORCIA G., COSTANTE G.
Subclinical visual field alterations are commonly present in patients with Graves’ Orbitopathy and are
mainly related to the clinical activity of the disease
Exp Clin Endocrinol Diabetes 116: 347-51, 2008 DOI 10.1055/s-2008-1042401
35. COSTANTE G., DURANTE D., ZÉLIA FRANCIS, SCHLUMBERGER M., FILETTI S.
Clinical interest of calcitonin determination in C cell disease
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Nat Clin Pract Endocrinol Metab 5:35-44, 2009.
36. COSTANTE G. FILETTI S.
Thyroglobulin in fine needle aspirate—a clue to metastasis?
Nat Rev Endocrinol 5:249-50, 2009
37. BRUNO R., GIANNASIO P., CHIARELLA R., CAPULA C., RUSSO D., FILETTI S., COSTANTE
G.
Identification of a Neck Lump as a Lymph Node Metastasis from an Occult Contralateral Papillary
Microcarcinoma of the Thyroid: Key role of Thyroglobulin Assay in the Fine needle Aspirate
Thyroid, 19: 531-533, 2009
38. CASTELLONE MC, VERRIENTI A, RAO DV, SPONZIELLO M, FABBRO D, MUTHU M,
DURANTE C, MARANGHI M, DAMANTE G, PIZZOLITTO S, COSTANTE G, RUSSO D, SANTORO
M, FILETTI S
A novel de novo germ-line V292M mutation in the extracellular region of RET in a patient with
pheochromocytoma and medullary thyroid carcinoma: Functional characterization.
Clin Endocrinol (Oxf). 73: 529-534, 2010
39. PAOLINO D.,COSCO D.,RACANICCHI L., TRAPASSO E., CELIA C., IANNONE M., PUXEDDU
E., COSTANTE G. FILETTI S., RUSSO D., FRESTA M.
Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR®: biodistribution,
pharmacokinetic features and in vivo antitumor activity
J Control Release, 144:144-150, 2010
40. DURANTE C, ATTARD M , TORLONTANO M, RONGA G, MONZANI F, COSTANTE G,
FERDEGHINI M, TUMINO S, MERINGOLO D, BRUNO R, DE TOMA G, CROCETTI U,
MONTESANO T, DARDANO A, LAMARTINA L, MANIGLIA A, GIACOMELLI L, FILETTI S, on behalf
of the PTC Study Group.
Identification and optimal postsurgical follow-up of patients with very-low-risk papillary thyroid
microcarcinoma
J. Clin Endocrinol Metab, 95:4882-4888. 2010
41. COSTANTE G. DURANTE C., MERINGOLO D., FILETTI S.
Calcitonin screening in patients scheduled for thyroidectomy for nodular disorders.
J. Clin Endocrinol Metab -- eLetters., 0 (2010) 201001621
http://jcem.endojournals.org/content/96/1/75.full/reply#jcem_el_84179
42. BRUNO R., GIANNASIO P., POGGIASPALLA M., CARBONE A., BELLITTI P., RUSSO D.,
COSTANTE G.
A case of anaplastic Diffuse Large B-Cell Thyroid Lymphoma: unique immunophenotype and unusual
clinical presentation.
J Endocrinol. Invest. 33:767-768, 2010
43. COSTANTE G. FILETTI S.
Early diagnosis of Medullary Thyroid Carcinoma: Should systematic Calcitonin screening be
performed in thyroid nodular disease patients?
The Oncologist, 16:49-52, 2011
44. RUSSO D., SCIPIONI A., DURANTE C., FERRETTI E., GANDINI L., MAGGISANO V., PAOLI D.,
VERRIENTI A., COSTANTE G., LENZI A., FILETTI S.
Expression and localization of the sodium/iodide symporter (NIS) in testicular cells.
Endocrine, 35-40: 2011. doi: 10.1007/s12020-011-9469-y. Epub 2011
45. RUSSO D, COSTANTE G, BRUNO R, SPONZIELLO M, TAMBURRANO G, DIMA M, SACCO R,
GIACOMELLI L, DURANTE C, FILETTI S.
TSH receptor extracellular region mutations in thyroid functioning nodules: further evidence for the
functional role of this region in the receptor activation.
Endocrine, 40:492-494, 2011
46. MERINGOLO D., BIANCHI D., CAPULA C., COSTANTE G.
Papillary thyroid carcinoma in struma ovarii.
Endocrine, 41: 164-165, 2012
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Giuseppe Costante
47. DURANTE C., MONTESANO T., ATTARD M., TORLONTANO M., MONZANI F., COSTANTE G.,
MERINGOLO D., FERDEGHINI M., TUMINO S., LAMARTINA L., PACIARONI A., MASSA M., G.
GIACOMELLI, RONGA G., FILETTI S., on behalf of the PTC Study Group
Long-term surveillance of papillary thyroid cancer patients who do not undergo postoperative
radioiodine remnant ablation: Is there a role for serum thyroglobulin measurement?
J. Clin Endocrinol. Metab. 97 : 2748-53, 2012
48. DURANTE C., MONTESANO T., TORLONTANO M., ATTARD M., MONZANI F., TUMINO S.,
COSTANTE G., MERINGOLO D, BRUNO R., TRULLI F., MASSA M., MANIGLIA A., GIACOMELLI
L., RONGA G., FILETTI S., on behalf of the PTC Study Group. Papillary thyroid cancer. Time course
of recurrences during post-surgery surveillance.
J. Clin Endocrinob Metab 98: 636-42, 2013.
49. DURANTE C, COSTANTE G, FILETTI S.
Differentiated thyroid carcinoma: defining new paradigms for the post-operative management.
Endocr Relat Cancer. 24;20:R141-54, 2013
50. ESSIG GF, PORTER K, SCHNEIDER D, DEBORA A, LINDSEY SC, BUSONERO G,
FINEBERG D, FRUCI B, BOELAERT K, SMIT JW, MEIJER JA, DUNTAS L, SHARMA N,
COSTANTE G, FILETTI S, SIPPEL RS, BIONDI B, TOPLISS DJ, PACINI F, MACIEL RM, WALZ PC,
KLOOS RT.
Fine needle aspiration and medullary thyroid carcinoma: the risk of inadequate preoperative
evaluation and initial surgery when relying upon FNAB cytology alone.
Endocr Pract. 2013 11:1-27.
51. CAPULA C, MAZZA T, VERO R, COSTANTE G
HbA1c levels in patients with gestational diabetes mellitus: relationship with pre-pregnancy body mass
index and pregnancy outcome.
J Endocrinol Invest. 2013 Jul 15. [Epub ahead of print] J Endocrinol Invest. 2013 Dec;36(11):1038-45.
doi: 10.3275/9037. Epub 2013 Jul 15.
52. CHIARELLA G, TOGNINI S, NACCI A, SIELI R, COSTANTE G, PETROLO C, MANCINI V,
GUZZI PH, PASQUALETTI G, CASSANDRO E, FATTORI B, RUSSO D, MONZANI F.
Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity.
Clin Endocrinol (Oxf). 2014 Apr 16. doi: 10.1111/cen.12471. [Epub ahead of print]
53. DURANTE C, TOGNINI S, MONTESANO T, ORLANDI F, TORLONTANO M, PUXEDDU E,
ATTARD M, COSTANTE G, TUMINO S, MERINGOLO D, BRUNO R, TRULLI F, TOTEDA M,
REDLER A, RONGA G, FILETTI S, MONZANI F. Clinical aggressiveness and long-term outcome in
patients with papillary thyroid cancer and circulating anti-thyroglobulin autoantibodies. Thyroid. 2014
Jul;24(7):1139-45. doi: 10.1089/thy.2013.0698. Epub 2014 May]
54. DURANTE C, COSTANTE G, LUCISANO G, BRUNO R, MERINGOLO D, PACIARONI A,
PUXEDDU E, TORLONTANO M, TUMINO S, ATTARD, M LAMARTINA L, NICOLUCCI A, FILETTI S
The Natural History of Benign Thyroid Nodules.
JAMA, 2015;313:926-935. doi:10.1001/jama.2015.0956
55. DE BIASE D, GANDOLFI G, RAGAZZI M, ESZLINGER M, SANCISI V, GUGNONI M, VISANI M,
PESSION A, CASADEI G, DURANTE C, COSTANTE G, BRUNO R, TORLONTANO M, PASCHKE
R, FILETTI S, PIANA S, FRASOLDATI A, TALLINI G, CIARROCCHI A.
TERT Promoter Mutations in Papillary Thyroid Microcarcinomas.
Thyroid. 2015;25:1013-1009. doi: 10.1089/thy.2015.0101
56. VERRIENTI A, CARBONE A, BELLITTI P, FABIANO MC, DE ROSE RF, MARANGHI M, LUCIA
P, DURANTE C, ROSIGNOLO F, PECCE V, SPONZIELLO M, PUPPIN C, COSTANTE G, BRUNO
R.
A novel double mutation val648ile and val804leu of ret proto-oncogene in multiple endocrine
neoplasia type 2.
Endocr Pract. 2015;21:1248-54. doi: 10.4158/EP15838.OR.
57. TALLINI G, DE BIASE D, DURANTE C, ACQUAVIVA G, BISCEGLIA M, BRUNO R, BACCHI
REGGIANI ML, CASADEI GP, COSTANTE G, CREMONINI N, LAMARTINA L, MERINGOLO D,
NARDI F, PESSION A, RHODEN KJ, RONGA G, TORLONTANO M, VERRIENTI A, VISANI M,
FILETTI S.
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Giuseppe Costante
BRAF V600E and risk stratification of thyroid microcarcinoma: a multicenter pathological and clinical
study.
Mod Pathol. 2015;28:1343-59. doi: 10.1038/modpathol.2015.92
58. BULOTTA S, CELANO M, COSTANTE G, RUSSO D.
Emerging strategies for managing differentiated thyroid cancers refractory to radioiodine.
Endocrine. 2016;52:214-21. doi: 10.1007/s12020-015-0830-4
59. SIDERIS S, AOUN F, MARTINEZ CN, LATIFYAN S, AWADA A, COSTANTE G, GIL T.
Role of corticosteroids in prostate cancer progression: implications for treatment strategy in metastatic
castration-resistant patients.
J Endocrinol Invest. 2016 Jul;39(7):729-38. doi: 10.1007/s40618-016-0430-z
60. LAMARTINA L, GRANI G, BIFFONI M, GIACOMELLI L, COSTANTE G, LUPO S, MARANGHI M,
PLASMATI K, SPONZIELLO M, TRULLI F, VERRIENTI A, FILETTI S, DURANTE C.
Risk stratification of neck lesions detected sonographically during the follow-up of differentiated thyroid
cancer.
J Clin Endocrinol Metab. 2016 Aug;101(8):3036-44. doi: 10.1210/jc.2016-1440
61. ESSIG GF JR, PORTER K, SCHNEIDER D, ARPAIA D, LINDSEY SC, BUSONERO G,
FINEBERG D, FRUCI B, BOELAERT K, SMIT JW, MEIJER JA, DUNTAS LH, SHARMA N,
COSTANTE G, FILETTI S, SIPPEL RS, BIONDI B, TOPLISS DJ, PACINI F, MACIEL RM, WALZ PC,
KLOOS RT.
Multifocality in Sporadic Medullary Thyroid Carcinoma: An International Multicenter Study.
Thyroid. 2016;26:1563-1572
PUBLICATIONS (Chapters)
C1. BENVENGA S. , SOBBRIO G., VERMIGLIO F., COSTANTE G., TRIMARCHI F.
T4 antibodies and thyroxine-binding globulin (TBG) immunoradiometric assay.
In Autoimmunity and the thyroid, P.G. Walfish and R. Volpé (Eds)
Academic Press, New York, 1985, p. 405.
C2. COSTANTE G., SAND G., CONNART D., GLINOER D.
Thyroid hormones regulate red blood cell Ca2+-dependent ATPase activity through a "non hormonal"
mechanism.
In Frontiers in Thyroidology, (G. Medeiros-Neto E. Gaitan Eds.),Plenum Publishing Co,Vol. I p. 661,
1986.
C3. FILETTI S., RUSSO D., FOTI D., COSTANTE G.
Recettore dell’ormone tireotropo: relazione tra struttura e funzione.
In Biologia cellulare e patologia endocrina: recenti acquisizioni in tema di disordini dello sviluppo e
della crescita Centro Auxologico Italiano, Milano, p. 32-37, 1991.
C4. BUZZETTI R., COSTANTE G., POZZILLI P.
Alcune prospettive per la medicina clinica. La biologia molecolare.
In Argomenti di Medicina Interna (A. Torsoli et al Eds) International University Press, p. 221-229, 1992.
C5. FILETTI S., COSTANTE G., FOTI D., SAVA L.
Thyroid diseases in the fetus.
In Thyroid diseases. Clinical fundamentals and therapy. (F. Monaco, M.A. Satta, B.S. Shapiro, L.
Troncone Eds). CRC Press Inc. p. 507-516, 1993.
C6. FOTI D., RUSSO D., COSTANTE G., FILETTI S.
Tecnologia del DNA ricombinante nello studio delle malattie tiroidee autoimmuni. Identificazione della
tireoperossidasi (TPO).
In Focus on 1991. A. Galluzzo, G. Bompiani Eds. CERD, Palermo, 1994, pp 145-153.
C7. COSTANTE G, PORTOLANO S., McLACHLAN S.M., RAPOPORT B.
Specific autoantibody binding to thyroid peroxidase: dominant role of the light chain in determining
epitope recognition.
In Highlights in molecular and clinical Endocrinology (M. Andreoli, M Shields Eds) ARES-SERONO
SYMPOSIA - Frontiers in Endocrinology Vol 9, pp. 37-40, 1994.
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C8. RUSSO D., ARTURI F., SCHLUMBERGER M., BRUNETTI A., CHIEFARI E., COSTANTE G.,
SUAREZ H.G., FILETTI S.
Thyrotropin receptor and thyroid tumorigenesis
Proceedings of the International Workshop Thyroid and Neuroendocrine Tumors: from Molecular
Biology to Clinical Oncology Taormina, 21-23 Novembre 1997. p.33-39
C9. RUSSO D., ARTURI F., CHIEFARI E. WONG M.G., CROCETTI U., COSTANTE G., CLARK
O.H., FILETTI S.
A hyperfunctioning Hurtle cell thyroid carcinoma with a mutation in the thyrotropin receptor
Proceedings of the International Workshop Biomedicina ‘97, Meeting on Molecular Medicine Firenze,
26-28 Novembre 1997, p. 182
C10. RUSSO D., ARTURI F., CHIEFARI E., COSTANTE G., CROCETTI U., FILETTI S.
Thyroid carcinoma and thyrotoxicosis
Proceedings of the International Workshop Thyroid Tumours Torino, 26-28 Marzo 1998, pp. 44-46
C11 COSTANTE G., FILETTI S.
Algoritmo diagnostico delle malattie tiroidee
In: La Tiroide. Diagnostica per immagini e approccio clinico ragionato. Lagalla, Latteri, Attard , Midiri
Eds, Idelson-Gnocchi, Napoli, 2003, pp. 77-85
C12 RUSSO D. ARTURI F., BRUNO R., COSTANTE G., CROCETTI U., D’ALOISO L., FERRETTI
E., PRESTA I., SCARPELLI D., FILETTI S.
Multiple endocrine neoplasia type 2
In: Update in Neuroendocrinology. From Basic research to clinical practice. Tamburrano Casanueva &
Baldelli Eds, Pubblicazioni Medico Scientifiche, Roma, 2004, pp. 292-297
C13 RUSSO D., ARTURI F., COSTANTE G., BRUNO R.
Patologie tiroidee da alterazioni del recettore del TSH.
In: La tiroide: Fisopatologia, diagnostica molecolare, clinica e terapia. A cura di Mario Andreoli. Il
Pensiero Scientifico Editore. 2004, pp. 211-222
C14 CARNOVALE-SCALZO G., PAOLA A., LABONIA AF., BRUZZICHESSI D, COSTANTE
G.,SCORCIA V., SCORCIA G.
Compressive optic neuropathy in patients with Thyroid Associated Ophthalmopathy.
Ophthalmic Res.36 (suppl 1) pp. 46-47, 2004
C15 COSTANTE G., DURANTE C., RUSSO D., FILETTI S.
Nuove acquisizioni nella patogenesi degli ipertiroidismi.
In: In cammino verso Scanno. Percorsi di storia e di scienza. Ardito, De Nardi, Anzi dei eds. GSE
Edizioni, Roma 2007. pp 177-184
C16 COSTANTE G., DURANTE C., MERINGOLO D., FILETTI S.
Carcinoma Midollare della Tiroide Familiare
In Trattato italiano di endocrinochirurgia: tiroide, paratiroidi, surrene, pancreas. L. Rosato Ed. Club
delle UEC, 2008, pp 214-220
C17 COSTANTE G.
Iodine status in individuals: an Italian perspective.
In: Comprehensive Handbook on Iodine: Nutritional, Endocrine and Pathological Aspects. Preedy,
Burrow, Watson Eds. Oxford:Academic Press, 2009, pp. 1179-1184.
C18 COSTANTE G., Meringolo D.
Il carcinoma Midollare della tiroide
In: I tumori tiroidei. Passato, presente e futuro.
Meringolo D. Ed. CLUEB, 2010, pp.141-146.
C19 FILETTI S., COSTANTE G., DURANTE C., PACINI F.
OFFICIAL ITALIAN TRANSLATION of the 2009 American Thyroid Association Management
Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer. American Thyroid
Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer.
Revised American Thyroid Association management guidelines for patients with thyroid nodules and
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differentiated thyroid cancer. Thyroid 2009;19:1167-214.
In: Clinical Thyroidology Volume 23 Issue 6 June 2011
C20 COSTANTE G.
Open questions on the diagnosis and treatment of thyroid tumours.
Rivista Medica
In press
C21 COSTANTE G.
Screening leading to diagnosis of C cell disease.
In : Thyroid cancer: a clinical casebook.
D. Cooper & C. Durante Eds. Springer, in press
PUBLICATIONS (Abstracts)
A1. BENVENGA S., COSTANTE G., TRIMARCHI F., DE LUCA F.,CONSOLO F.
Legame anomalo degli ormoni tiroidei causa di ipotiroidismo in un caso di Macroglobulinemia di
Waldenstrom.
J. Endocrinol. Invest. 3 (suppl. ) : 66, 1980
A2. BENVENGA S., COSTANTE G., MELLUSO R., LUZZA G., PUSTORINO S., TURIANO S.,
TRIMARCHI F.
Assenza di effetti inibitori delle immunoglobuline M sul legame degli ormoni tiroidei alle proteine
plasmatiche nel siero di pazienti con gravi malattie non tiroidee (NTI).
J. Endocrinol. Invest. 4 (suppl. 2) : 42, 1981.
A3. TRIMARCHI F., BENVENGA S., BARBERA C., COSTANTE G., DE LUCA F., MELLUSO R.,
CONSOLO F.
Caratterizzazione degli auto-anticorpi circolanti anti T3 e anti T4
J. Endocrinol. Invest. 4 (suppl. 2) : 43, 1981.
A4. DE LUCA F., TRIMARCHI F., SFERLAZZAS C., BENVENGA S., MAMI' C., COSTANTE G.,
MAGAZZU' G.
Il trasporto sierico degli ormoni tiroidei nella fibrosi cistica del pancreas.
Riv. Ital. Ped. 7 : 444, 1981.
A5. BENVENGA S., TRIMARCHI F., COSTANTE G., CONSOLO F.
Deficit ereditario di TBG associato a multipli disordini endocrini e non: studio di una famiglia.
Atti del Congresso I Giornate Toscane della Tiroide, Firenze, 9-10 .Gennaio 1981, p. 45.
A6. DE LUCA F., TRIMARCHI F., SFERLAZZAS C., BENVENGA S., COSTANTE G., DI PASQUALE
G., MAGAZZU' G.
Adattamento funzionale della tiroide nella mucoviscidosi.
Atti III Congresso della Società Italiana di Endocrinologia e Diabetologia Pediatrica, Montecatini
Terme, 16-18 Ottobre 1981, p. 85.
A7. BENVENGA S., MELLUSO R., COSTANTE G., TRIMARCHI F.
Il trasporto degli ormoni tiroidei nelle gravi malattie non tiroidee (NTI).
Atti del Congresso II Giornate Toscane della Tiroide, Pisa 12-13 Marzo 1982, p. 88.
A8. TRIMARCHI F., BENVENGA S., COSTANTE G., BARBERA C.,
CONSOLO F.
Anticorpi circolanti anti-tironine in malattie tiroidee, in malattie non tiroidee auto-immunie in disordini
del sistema linforeticolare.
J. Endocrinol. Invest. 5 (suppl. 1) : 79, 1982.
A9. BENVENGA S., TRIMARCHI F., BARBERA C., MORABITO S., COSTANTE G. , BARBERIO G.,
CONSOLO F.
Immunoglobulin E (Ig-E) mediated allergy to l-thyroxine.
Ann. Endocrinol. 43 : 61 A, 1982.
A10. COSTANTE G. , SAND G., GLINOER D.
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Characterization of native and desialylated TBG by immunochemical tecniques.
J. Endocrinol. Invest. 6 (suppl. 1) : 60, 1983.
A11. BENVENGA S., SOBBRIO G., MELLUSO R., COSTANTE G., TRIMARCHI F.
Studies on the interference of T4 binding immunoglobulins on TBG immunoradiometric assay.
J. Endocrinol. Invest. 6 (suppl 1) : 64, 1983.
A12. COSTANTE G., SAND G., REDING P., JONAS C., GLINOER D.
Characteristics of circulating thyroxine-binding globulin in liver disease.
Proc. of the 59th Annual Meeting of the American Thyroid Association, New Orleans, October 6-8,
1983.
Endocrinology 113 (suppl.) T-50, 1983.
A13. COSTANTE G., SAND G., REDING P., JONAS C., GLINOER D.
Characteristics of circulating thyroxine-binding globulin in liver disease.
Eur J. Clin Invest. 14 (Part II) : 25, 1984.
A14. BENVENGA S., SOBBRIO G., VERMIGLIO F., COSTANTE G.,
TRIMARCHI F.
T4 antibodies and thyroxine-binding globulin (TBG) immunoradiometric assay.
J. Steroid Biochem. 20 (6B) : 1653, 1984
A15. COSTANTE G., SAND G., CONNART D., GLINOER D.
In vitro effects of thyroxine on erythrocyte Ca2+-dependent ATPase.
J. Endocrinol Invest. 8 (suppl. 1) 55, 1985.
A16. COSTANTE G., SAND G., CONNART D., GLINOER D.
Thyroid hormones regulate red blood cell Ca2+-dependent ATPase activity through a "non hormonal"
mechanism.
Proceed. 9th International Thyroid Congress, São Paulo-Brazil, September 1-6 1985 Abst. 105.
A17. COSTANTE G., DEMEESTER-MIRKINE N., SOBBRIO G. A., CONSOLO F.,TRIMARCHI F.
Ipotiroidismo periferico nel corso della gravidanza in una paziente in trattamento con l-tiroxina.
Atti del Congresso IV Giornate Italiane della Tiroide, Messina-Taormina, 11-13 Dicembre 1986, p. 143.
A18. CANNAVO' S., COSTANTE G., LI CALZI L., ARAGONA A., CRUPI D., TRIMARCHI F.
Circulating prolactin immunoreactivity in hyperprolactinemia: discrepancy between radioimmunoassay
and immunoradiometric assay.
J. Endocrinol Invest 10 (suppl. 1) : 22, 1987.
A19. COSTANTE G., CANNAVO' S., LI CALZI L., ARAGONA A., CRUPI D., TRIMARCHI F.
Immunoreactivity of human prolactin in normal subjects and hyperprolactinemic patients. Comparison
between radioimmunoassay and immunoradiometric assay.
Proc. 3rd Meeting of the European Neuroendocrine association, London September 9-11 1987, p. 97.
A20. COSTANTE G., CRUPI D., TRIMARCHI F.
Effetto della T4 somministrata per os sulla induzione dell'alfa-glicerolo fosfato deidrogenasi dei
mitocondri epatici di ratto.
Atti del Congresso V Giornate Italiane della Tiroide, Parma 4-6 Novembre, 1987, p. 40.
A21. CRUPI D., CATALFAMO R., COSTANTE G.
Effect of small doses of l-thyroxine on liver mitochondrial alpha-glycerophosphate dehydrogenase and
serum TSH levels in Thyroidectomized rats.
J. Endocrinol. Invest. 11 (suppl. 2) : 54, 1988.
A22. COSTANTE G. , CRUPI D., TRIMARCHI F.
Effect of active immunization against l-triiodothyronine on rat liver mitochondrial alphaglycerophosphate dehydrogenase.
J. Endocrinol. Invest. 11 (suppl. 2) : 56, 1988.
A23. COSTANTE G., CRUPI D., CATALFAMO R., TRIMARCHI F.
Attività alfa-glicerolofosfato deidrogenasica mitocondriale epatica e livelli di TSH circoloanti in ratti
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immunizzati contro la l-triiodotironina.
Atti del Congresso VI Giornate Italiane della Tiroide, Bari 8-10 Dicembre 1988, p. 30.
A24. CATALFAMO R., COSTANTE G., CRUPI D., MELLUSO R., TRIMARCHI F.
Studio comparativo dell'attività tireostimolante del siero di ratti normali ed immunizzati contro la l-T3
sulle cellule tiroidee FRTL-5.
Atti del Congresso VI Giornate Italiane della Tiroide, Bari 8-10 Dicembre 1988, p. 36.
A25. COSTANTE G. , CRUPI D., CATALFAMO R., TRIMARCHI F.
Thyroid hormone binding autoantibodies (THbAb) may induce "peripheral" hypothyroidism in rats.
Ann. Endocrinol 50 : 100, 1989.
A26. FILETTI S., RUSSO D., FOTI D., COSTANTE G., DAMANTE G., FUSCO A.
High levels of glucose transport in thyroid cells transformed with oncogenic viruses : study on
molecular mechanisms.
J. Endocrinol Invest. 13 (suppl. 1) : 7, 1990.
A27. COSTANTE G., MAZZEI A.M., FILETTI S.
The binding sites for bovine and human TSH are different in human thyroid cells: the biological activity
of TSAb is related to the human TSH binding site.
J. Endocrinol. Invest. 13 (suppl. 1) : 19, 1990.
A28. COSTANTE G., FOTI D., FILETTI S.
Recettore ricombinante umano del TSH: utilizzo nella determinazione degli anticorpi anti-recettore del
TSH.
Atti del Congresso VIII Giornate Italiane dell Tiroide, Cagliari 5-7 dicembre 1990, p. 65.
A29. FOTI D., CATALFAMO R., COSTANTE G., GRASSO G., FILETTI S.
Recombinant human TSH receptor in a radioreceptor assay for the measurement of the TSH receptor
antibodies.
25th Annual Meeting of the European Society for Clinical Investigation,Pisa, 1991 Abstract No 382.
Workshop 15 "New developments on thyroid autoimmunity: the immunology of the TSH receptor".
A30. FOTI D., RUSSO D., COSTANTE G., GRASSO G., CATALFAMO R.,
FUSCO A., FILETTI S.
Molecular mechanisms involved in the increse of glucose transport in transformed FRTL5 thyroid
cells.
Proc. of The Endocrine Society Annual Meeting. Washington D.C. June 1991, Abstract 536, p. 164.
A31. COSTANTE G., VERMIGLIO F., BATTIATO S., TRIMARCHI F., GRASSO L., LOVISELLI A.,
FILETTI S.
Identificazione e caratterizzazione di una nouva area di endemia gozzigena in Calabria.
Atti del Congresso IX Giornate Italiane della Tiroide. Udine 5-7 dicembre 1991. p. 160
A32. FILETTI S., COSTANTE G., RUSSO D., FOTI D.
Ipotiroidismo:diagnostica di laboratorio.
La diagnostica di laboratorio in medicina generale. Roma, Italy, 20-21 febbraio 1992
A33. COSTANTE G., PORTOLANO S., CHAZENBALK G., McLACHLAN S.M., RAPOPORT B.
The binding to thyroperoxidase (TPO) by TPO autoantibodies requires specific heavy and light chain
combionations.
J. Endocrinol. Invest.16 (suppl. to N.4): 4, 1993.
A34. COSTANTE G., PORTOLANO S., NISHIKAWA T., CHAZENBALK G.D., McLACHLAN S.M.
No tolerance for different heavy (H) and light (L) chain combinations for autoantibody binding to
epitopes on thyroid peroxidase (TPO): implications for the controversy on whether H and L chain
associations in combinatorial libraries are the same as in vivo.
Proc. of 67th Annual Meeting of The American Thyroid Association Tampa, nov. 10-14, 1993 Abs 89
p. T-45.
A35. CHAZENBALK G.D., COSTANTE G.
The immunodominant region on human thyroid peroxidase recognizedby autoantibodies does not
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Giuseppe Costante
contain the Mab 47/C21 linear epitope.
Proc. of 67th Annual Meeting of The American Thyroid Association Tampa, nov. 10-14, 1993 Abs 120
p. T-61.
A36. RAPOPORT B., NISHIKAWA T., PORTOLANO S., CHAZENBALK G., COSTANTE G.,
McLACHLAN S.
Autoantibody epitopes in autoimmune thyroid disease: potential clinical importance.
J. Endocrinol. Invest. 17 (suppl. 2, abs WO 23): 16, 1994.
A37. COSTANTE G. , PORTOLANO S., McLACHLAN S., RAPOPORT B..
Specific autoantibody binding to thyroid peroxidase: dominant role of the light chain in determining
epitope specificity.
J. Endocrinol. Invest. 17 (suppl. 2, abs OC 50): 31, 1994.
A38. JAUME J.C., COSTANTE G., PORTOLANO S., McLACHLAN S., RAPOPORT B.
Recombinant thyroid peroxidase - specific autoantibodies: how diverse is the pool of heavy and light
chains in immunoglobulin gene libraries constructed from thyroid tissue - infiltrating plasma cells ?
Proc. of the Endocrine Society Annual Meeting. Anaheim - CA, June 15-18, 1994, Abs 1265, p.517.
A39. COSTANTE G., JAUME J. C. PHILLIPS D. J.W., RAPOPORT B., McLACHLAN S.
Caratterizzazione degli epitopi riconosciuti dagli anticorpi anti-tireoperossidasi presenti nel siero di
donne anziane eutiroidee e con ipotiroidismo.
Atti del Congresso XII Giornate Italiane della Tiroide. Ancona 1-3 dicembre 1994. p. 116
A40. COSTANTE G., SCHIFINO E., CELICO L., LUDOVICO O., NOCERA M., VERALDI R.,
BEVIVINO E., RIVALTA L., APA G., MARASCO M.F., CROCETTI U., CHIARELLA R., PARLATO G.
Congenital hypothyroidism screening programs can be used for the surveillance of iodine deficiency
areas.
J. Endocrinol Invest. 18 ( suppl. to N 5): 62, 1995
A41. COSTANTE G., LUDOVICO O., NOCERA M., PARLATO G., SCHIFINO E., MARASCO M.F.,
CROCETTI U., CAPULA C., FILETTI S.
Congenital hypothyroidism screening programs provide a sensitive method for the identification of
populations at risk for endemic goiter.
Proc..of the 11th International Thyroid Congress, Toronto-Canada, September 10-15, 1995.
Thyroid, 5 (suppl. 1, abs 42): S-21, 1995
A42. SCHIFINO E., MARASCO M.F., CHIARELLA R., CROCETTI U., LUDOVICO O., NOCERA M.,
CAPULA C., COSTANTE G., PARLATO G., FILETTI S.
Caratterizzazione della carenza iodica in Calabria: confronto tra le indagini epidemiologiche sul
territorio e i risultati dello screening neonatale per l'ipotiroidismo congenito.
Atti del Congresso XIII Giornate Italiane della Tiroide. Bologna 30 novembre-2 dicembre 1995. p. 111
A43 MARASCO M.F., CAPULA C., ARTURI F., CHIARELLA R., CROCETTI U., LUDOVICO O.,
NOCERA M., SCHIFINO E., BRUNETTI A., FILETTI S., COSTANTE G.
Effectiveness of L-thyroxine treatment for the prevention of nodular goiter recurrence in an endemic
goiter area.
J. Endocrinol. Invest. 19 ( Suppl. to N 5): 48, 1996.
A44 CHIEFARI E., MERINGOLO D., RUSSO D., BIANCHI D., ARTURI F., GALLO C., COSTANTE
G., ZAMPA G.A., FILETTI S.
Early identification of a ret proto-oncogene somatic mutation in fine needle aspiration biopsy (FNAB)
of a medullary thyroid carcinoma.
J. Endocrinol. Invest. 20 (Suppl. to N 4): 8, 1997.
A45. ARTURI F., WONG M.G., RUSSO D., CROCETTI U., COSTANTE G., FILETTI S., CLARK O.
An activating mutation in the thyrotropin receptor causing thyrotoxicosis in a Hurtle cell thyroid
carcinoma
Atti International Workshop Thyroid and Neuroendocrine Tumors: from Molecular Biology to Clinical
Oncology, Taormina, 21-23 Novembre 1997. p. 182
A46. LUDOVICO O., CAPULA C., CROCETTI U., CHIARELLA R., NOCERA M., MARASCO M.F.,
SCHIFINO E., CATALANO S., BRUNETTI A., FILETTI S., COSTANTE G.
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Efficacia della terapia con L-tiroxina nella riduzione del volume dei noduli tiroidei in donne in
menopausa
Atti del Congresso XV Giornate Italiane della Tiroide. Venezia 4-6 dicembre 1997. P5-12
A47 CAPULA C., LUDOVICO O., ARTURI F., CROCETTI U., MARASCO M.F., SCHIFINO E.,
CHIARELLA R., NOCERA M., CHIEFARI E., FERRARO C., NICOTERA M., FILETTI S., COSTANTE
G.
Recurrence of nodular goiter: evidence for a prophylactic role of postoperative l-thyroxine treatment in
a moderate iodine deficiency area.
J. Endocrinol. Invest. 22 (Suppl. to N 6): 95, 1999
A48 ARTURI F., TORRENTE I., SCARPELLI D., D’ALOISO L., COSTANTE G., CRISTOFARO C.,
PRESTA I., FERRETTI E., RUSSO D., FILETTI S.
RET analysis in inherited medullary thyroid carcinoma: new mutations and rapid detection methods.
J. Endocrinol. Invest.26 (Suppl. to N6): 30, 2003
A 49 CROCETTI U., D’ALOISO L., AUGELLO G., BONFITTO N., MODONI S., VARRASO A.,
FRUSCIANTE V., BISCEGLIA M., DI GIORGIO A., BRUNO R., COSTANTE G., TRISCHITTA V.,
FILETTI S., TORLONTANO M.
First follow up of low risk patients with differentiated thyroid cancer after recombinant TSH stimulation.
J. Endocrinol. Invest.26 (Suppl. to N6):31, 2003
A50 TORLONTANO M., ATTARD M., ARTURI F., BRUNO R., COSTANTE G., CROCETTI U.,
D’AZZO’ G., MERINGOLO D., SACCO R., TUMINO S., TRISCHITTA V., FILETTI S.
Neck ultrasonography in the follow up of low risk patients with papillary thyroid cancer.
J. Endocrinol. Invest.26 (Suppl. to N6):32, 2003
A51 COSTANTE G., CROCETTI U., SCHIFINO E., LUDOVICO O., NICOTERA M., CAPULA C.,
CHIARELLA R., NOCERA M., ARTURI F., SACCO R., FILETTI S.
L-thyroxine suppressive treatment has no beneficial effect on thyroid nodules after menopauese.
J. Endocrinol. Invest.26 (Suppl. to N6):39, 2003
A52 CROCETTI U., ATTARD M., ARTURI F., BRUNO R., COSTANTE G., D’AZZÒ G., MERINGOLO
D., SACCO R., TUMINO S., FILETTI S., TORLONTANO M.
Ruolo dell’ecografia del collo nel follow up a 5 anni dei pazienti affetti da carcinoma papillifero a basso
rischio .
Atti del Congresso XXV Giornate Italiane della Tiroide, Chieti 27-29 Novembre 2003. p.134
A53 CARNOVALE SCALZO G, PAOLA A, LABONIA AF, BRUZZICHESSI D, COSTANTE G,
SCORCIA V, SCORCIA G
Compressive optic neuropathy in patients with Thyroid Associated Ophthalmopathy (TAO)
Ophtalmic Res.36 (suppl. 1): 49, 2004
A54 NOCERA M., BIANCHI D., ARTURI F., COSTANTE G., FILETTI S., MERINGOLO D.
Diagnosi preoperatoria di carcinoma midollare della tiroide in pazienti affetti da gozzo multinodulare:
utilità del dosaggio rutinario della calcitonina serica.
Atti del Congresso XXII Giornate Italiane della Tiroide, Salerno, 2-4- Novembre 2004, p. 109.
A55 LABONIA AF, CARNOVALE SCALZO G, PAOLA A, SCORCIA V, DE MORELLI G,
BRUZZICHESSI D, SCORCIA G, COSTANTE G.
Subclinical optic nerve involvement in patients with thyroid-associated ophthalmopathy
J. Endocrionol Invest 28 (suppl. 1): 322, 2005.
A56 COSTANTE G, MERINGOLO D, NOCERA M, BIANCHI D, TUMINO S, CROCETTI U, ATTARD
M, TORLONTANO M, FILETTI S.
Screening per carcinoma midollare della tiroide: accuratezza diagnostica del dosaggio sistematico
della calcitonina sierica nei noduli tiroidei
Atti del Congresso XXIII Giornate Italiane della Tiroide (Torino 1-3 Dicembre 2005), p. 65
A57 TORLONTANO M, CROCETTI U, BISCEGLIA L, DE BONIS P, AUGELLO G, D’ALOISO L,
MERINGOLO D, BIANCHI D, TUMINO S, LOCOCO R, ATTARD M, D’AZZÒ G, COSTANTE G,
BRUNO R, ZELANTE L, FILETTI S.
L’analisi di linkage dimostra una possibile associazione con alcuni loci cromosomici in famiglie affette
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da tiroidite cronica autoimmune
Atti del Congresso XXIII Giornate Italiane della Tiroide (Torino 1-3 Dicembre 2005), p. 179
A58 CLORO C, LABONIA A, COSTANTE G, ARTURI F.
Un raro caso di Basedow monolaterale intollerante al trattamento con tionamidi
Atti del Congresso XXIII Giornate Italiane della Tiroide (Torino 1-3 Dicembre 2005), p. 206
A59 SCIPIONI A, FERRETTI E, TOSI E, AMOROSI A, SACCO R, INNARO N, SODA G, NARDI F,
ARTURI F, RUSSO D, MERINGOLO D, FOSCHINI MP, FILETTI S, COSTANTE G.
Studio in vivo dell’espressione e della localizzazione della proteina hnis nei noduli tiroidei in aree a
diverso apporto iodico
Atti del Congresso XXIII Giornate Italiane della Tiroide (Torino 1-3 Dicembre 2005), p. 216
A60 CLORO C, LABONIA A, COSTANTE G, FERACO E, ARTURI F.
Ruolo dell’ipertiroidismo subclinico nella comparsa di fibrillazione atriale nei pazienti in età avanzata
Atti del Congresso XXIII Giornate Italiane della Tiroide (Torino 1-3 Dicembre 2005), p. 249
A61 LABONIA A.F; CARNOVALE SCALZO G.;. PAOLA A; SCORCIA V.; DE MORELLI G.;
BRUZZICHESSI D; SCORCIA G.; COSTANTE G.
Characterization of visual field alterations in patients with Thyroid Associated Ophthalmopathy
J. Endocrionol Invest 29 (suppl. 1): 26, 2006
A62 CLORO C, LABONIA A. F., COSTANTE G., FERACO E. , ARTURI F
Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in elderly subjects.
J. Endocrionol Invest 29 (suppl. 1): 27, 2006
A63 LABONIA A.F, CARNOVALE SCALZO G.,. PAOLA A, SCORCIA V.;, DE MORELLI G.,
BRUZZICHESSI D., SCORCIA G., COSTANTE G.
Subclinical visual field alterations in thyroid associated ophthalmopathy patients.
Hot Thyroidology - Abstract Book of the 31st Eurpean Thyroid Association, Naples (Italy) September
2nd-6th 2006, p. 87
A64 CARNOVALE SCALZO G, LABONIA AF, PAOLA A, SCORCIA V, SCORCIA GB,
BRUZZICHESSI D, COSTANTE G, SCORCIA G
Early diagnosis of compressive optic neuropathy (NOC) in patients with Thyroid Autoimmune
Ophthalmopathy (TAO)
Proceedings of the Meeting of the European Association for Eye Research and Vision, Villamoura
(Portugal) October 4-7, 2006, p 53.
A65 CLORO C., LABONIA A.F., COSTANTE G., FERACO E. , ARTURI F.
Ruolo aritmogeno dell’ipertiroidismo subclinico: bassi livelli di TSH come fattore di rischio per la
comparsa della fibrillazione atriale nei soggetti anziani
Giornale Italiano di Cardiologia, Vol. 7, Suppl. 1-12, 58S, 2006
A66 CARNOVALE SCALZO G, LABONIA AF, PAOLA A, SCORCIA V, SCORCIA GB,
BRUZZICHESSI D, COSTANTE G, SCORCIA G
Early diagnosis of compressive optic neuropathy (NOC) in patients with Thyroid Autoimmune
Ophthalmopathy (TAO)
Proceedings of the Meeting of the European Association for Eye Research and Vision, Villamoura
(Portugal) October 4-7, 2006, p 53
A67 CLORO C., LABONIA A.F., COSTANTE G., FERACO E. , ARTURI F.
Ruolo aritmogeno dell’ipertiroidismo subclinico: bassi livelli di TSH come fattore di rischio per la
comparsa della fibrillazione atriale nei soggetti anziani
Giornale Italiano di Cardiologia, Vol. 7, Suppl. 1-12, 58S, 2006
A68 CLORO C., LABONIA A.F., COSTANTE G., ARTURI F.
Un raro caso di morbo di Basedow monolaterale intollerante al trattamento con tionamidi
Atti VIII Congresso Interregionale S.I.M.I. Calabria e Sicilia, 39
Vibo Valentia, 19-21 Aprile 2007
A69 SCARPELLI D., PRESTA I,. LABONIA AF, COSTANTE G., ARTURI F.
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Curriculum vitae
Giuseppe Costante
MEN1 and HRPT2 gene mutations in patients with sporadic primary hyperparathyroidism
J. Endocrinol. Invest. Vol. 30, Suppl. 4, 10, 2007
A70 SCARPELLI D., PRESTA I,. LABONIA AF, COSTANTE G., ARTURI F.
RET gene polymorphisms in sporadic forms of medullary thyroid carcinoma
J. Endocrinol. Invest. Vol. 30, Suppl. 4, 86, 2007
A71 VARANO L., CAMPAGNA F., BRUZZICHESSI D., CARNOVALE SCALZO G., PAOLA A.,
RUSSO C., SCORCIA V., PARISE S., ARTURI F., COSTANTE G., SCORCIA G.
Correlation between saccadic parameter variations and clinical evidences in thyroid autoimmune
ophthalmopathy (TAO) affected patients
Acta Ophtalmologica Scandinavica, Vol. 85, Issue S240, abs 3370, 2007
A72 CLORO C., FERACO E., LABONIA A.F., COSTANTE G., ARTURI F.
Fibrillazione atriale nei soggetti anziani: ruolo aritmogeno dell’ipertiroidismo subclinico
Internal and Emergency Medicine, Vol.2 , Issue 1828-0447, S127, 2007
A73 BUCCINNA’ T., SUCCURRO E., PERTICONE M., CLORO C., COSTANTE G., ARTURI F.
Soppressione del TSH in pazienti trattati con metformina: associazione casuale o interazione
farmacologica?
Atti XXV Giornate Italiane della Tiroide, OC7
Ancona, 29-30 Novembre/1Dicembre 2007
A74 VARANO L., CAMPAGNA F., BUCCINNA’ T, BRUZZICHESSI D., CARNOVALE SCALZO G.,
PAOLA A., RUSSO C., SCORCIA V., PARISE S., SCORCIA G., COSTANTE G., ARTURI F.
Correlazione tra le modifiche dei parametri saccadici e le manifestazioni cliniche nei pazienti con
oftalmopatia tiroidea autoimmune
Atti XXV Giornate Italiane della Tiroide, P78
Ancona, 29-30 Novembre/1Dicembre 2007
A75 VARANO L., CAMPAGNA F., CARNOVALE SCALZO G., PAOLA A., ARTURI F., BUCCINNA’ T.,
COSTANTE G., SCORCIA G., BRUZZICHESSI D.
Correlation between saccadic parameter variations and clinical evidences in thyroid autoimmune
ophthalmopathy (TAO) affected patients
Atti Giornata Scientifica 2008-Università Magna Graecia di Catanzaro, P137, Catanzaro, 12 Marzo
2008
A76 BUCCINNA’ T., CLORO C., LABONIA A. F., COSTANTE G., ARTURI F.
Low serum Thyrotropin concentrations as a risk factor for atrial fibrillation in elderly subjects.
Atti Giornata Scientifica 2008-Università Magna Graecia di Catanzaro, P170, Catanzaro, 12 Marzo
2008
A77 SCARPELLI D. , PRESTA I., LABONIA A.F., COSTANTE G., F. ARTURI
MEN1 and HRPT2 gene mutations in patients with sporadic primary hyperparathyroidism
Atti Giornata Scientifica 2008-Università Magna Graecia di Catanzaro, P72. Catanzaro, 12 Marzo
2008
A78 SCARPELLI D. , PRESTA I., LABONIA A.F., COSTANTE G., F. ARTURI
RET gene polymorphisms in sporadic forms of medullary thyroid carcinoma
Atti Giornata Scientifica 2008-Università Magna Graecia di Catanzaro, P71, Catanzaro, 12 Marzo
2008
A79 LABONIA A.F; CARNOVALE SCALZO G.;. PAOLA A; SCORCIA V.; DE MORELLI G.;
BRUZZICHESSI D; SCORCIA G.; COSTANTE G.
Subclinical visual field alterations in patients with thyroid orbitopaty
Atti Giornata Scientifica 2008-Università Magna Graecia di Catanzaro, P141, Catanzaro, 12 Marzo
2008
A80 ARTURI F., CLORO C., SUCCURRO E., BUCCINNA’ T., COSTANTE G.
Metformin therapy decreases serum TSH levels in patients submitted to l-thyroxine treatment.
Thyroid. Vol. 18 (NS1), p S 26 Abs n.53, 2008
A81 BRUNO R., GIANNASIO P., BELLITTI P., CHIARELLA R., CAPULA C., RUSSO D., FILETTI S.,
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Curriculum vitae
Giuseppe Costante
COSTANTE G.
Tumefazione cervicale identificata come metastasi linfonodale da microcarcinoma tiroideo papillare
controlaterale: ruolo chiave per la diagnosi la presenza di tireoglobulina nel materiale agoaspirato
A82 D’AGOSTINO M, PAOLINO D, COSCO D, CELANO M, RACANICCHI L, TRAPASSO E, CELIA
C, IANNONE M, PUXEDDU E, COSTANTE G, RUSSO D, FRESTA M,
Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR®: biodistribution,
pharmacokinetic features and in vivo antitumor activity
A83 DURANTE C,, ATTARD M, TORLONTANO M, RONGA G., MONZANI F., COSTANTE G.,
TUMINO S., MERINGOLO D., FERDEGHINI M., BRUNO R., MONTESANO T., GIACOMELLI L.,
FILETTI S.
,A pivotal role for neck Ultrasonography in the follow-up management of clinically selected very lowrisk Papillary Thyroid Microcarcinoma patients
Proc XIV International Thyroid Congress – Paris 11-16 September 2010 – Abs n P0183
A84 BRUNO R., SPONZIELLO M., DURANTE C., D'AGOSTINO M.,. CORRADINO R, GIANNASIO
P., VERRIENTI A., GIACOMELLI L., COSTANTE G., RUSSO D.
Chronic thyrotropin suppression does not affect growth factor receptor gene expression and Akt
phosphorylation in benign human thyroid nodules
Proc XIV International Thyroid Congress – Paris 11-16 September 2010 – Abs n P0317
A85 TORLONTANO M., ATTARD M., DURANTE C., MASSA M., CROCETTI U., RONGA G.,
MONTESANO T., MONZANI F., COSTANTE G., TUMINO S., MERINGOLO D., FERDEGHINI M.,
BRUNO R., FILETTI S.
Very-low risk” papillary thyroid micro-carcinoma: which treatment and follow-up?
Atti IV Congresso Associazione Italiana della Tiroide, P.123
Campobasso, 2-4 Dicembre 2010
A86 MERINGOLO D., BIANCHI D., CAPULA C., COSTANTE G.
Unifocal papillary thyroid microcarcinoma in a large struma ovarii associated to endometriotic cyst
J. Endocrinol. Invest 34 (Suppl. 3): 56, 2011.
A87 CAPULA C., VERO R., PULLANO V., MAZZA T., COSTANTE G.
Influence of pre-pregnancy body mass index on maternal and fetal outcomes on gestational diabetic
women
J. Endocrinol. Invest 34 (Suppl. 3): 84, 2011.
A88 CAPULA C., VERO R., PULLANO V., MAZZA T., COSTANTE G.
Frequency of early postpartum glucose tolerance abnormalities in patients with history of gestational
diabetes mellitus
J. Endocrinol. Invest 34 (Suppl. 3): 84, 2011.
A89 DURANTE C., COSTANTE G., RONGA G., ARGIRÒ G. GIUFFRIDA, D. , MONZANI F. ,
TUMINO S. , ORLANDI F. PONTECORVI A., BARBARO D., TORLONTANO M., MONTESANO T.,
AMMENDOLA M., MEMEO L., RUSSO D., FILETTI S.
Familial differentiated thyroid cancer: a distinct clinical entity?.
Proceedings 84th Meeting American Thyroid Association. Quebec City, Canada 19-23-sept. 2012.
Abst. 167
A90 DURANTE C., COSTANTE G., BRUNO R., MERINGOLO D. , TORLONTANO M., ATTARD M. ,
PUXEDDU E. , TUMINO S. , ACCA M. CROCETTI U., D’ALOISO L. CAPULA C., PACIARONI A.,
FILETTI S.
THE NATURAL HISTORY OF THE BENIGN NODULE.
Proceedings 84th Meeting American Thyroid Association. Quebec City, Canada 19-23-sept. 2012.
Abst. 168
Projects
1999-2001 CEE (European structural funds) in collaboration with the Italian Ministry of Education and
the Italian Research Council project “Eradication of endemic goiter and iodine deficiency in southern
Italy”
2002 Italian Ministry of Education project n. 2002062899_002
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Curriculum vitae
Giuseppe Costante
2003 Italian Ministry of Education project n. 2003069778_003
2004-2007 Italian Ministry of Education project n. 2004065181_002
2008-2011 Italian Ministry of Education project n. 200845P777_002
2013-2014 Expert Accompagnant, projet “Organisation of care for adults with a rare or complex
cancer”, Centre Féderal d’Expertise des Soins de Santé (KCE), Belgium.
Memberships
Belgian Society of Endocrinology
Endocrine Society
American Thyroid Association
European Thyroid Association
Other Relevant Information
Member of the Editorial Board of The Journal of Endocrinological Investigation
Manuscript revision for the following journals:
Clinical Endocrinology
Endocrine
European Journal of Endocrinology
Experimental and Clinical Endocrinology & Diabetes
Hormones
Journal of Clinical Endocrinology and Metabolism
Journal of Endocrinological Investigation
Journal of Experimental and Clinical Cancer Research
Nature Reviews Endocrinology
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