Paola Cinque - EMA

Curriculum vitae
PERSONAL INFORMATION
Paola Cinque
WORK EXPERIENCE
July 1987–July 1991
Fellow
Clinic of Infectious Diseases, Luigi Sacco Hospital, University of Milan, , (Italy)
October 1987–July 1991
Consultant
Blood Transfusion Unit, Sesto San Giovanni Hospital, Italy, (Italy)
August 1991–October 1993
Visiting Scientist
Karolinska Institute, (Sweden)
October 1993–Present
Faculty Member
San Raffaele Hospital/Scientific Institute, Department of Infectious Diseases, Milano, (Italy)
January 1999–Present
Head of Clinical Research Group
San Raffaele Hospital/Scientific Institute, Milano, (Italy)
March 1999–Present
Contract Professor
San Raffaele University, (Italy)
June 2009–May 2013
Program Director
San Raffaele Hospital/Scientific Institute, Research Division of Immunology, Transplantation and
Infectious Diseases, San Raffaele Scientific Institute, Milan, (Italy)
EDUCATION AND TRAINING
September 1981–October 1987
M.D.
University of Milano, (Italy)
November 1987–July 1991
Specialisti in Infectious Diseases
University of Milano, (Italy)
August 1991–October 1993
Ph.D.
Karolinska Institute, (Sweden)
ADDITIONAL INFORMATION
Expertise
Vira infezione of the central nervous system
Progressive multifocal leukoencephalopathy
HIV infection of the central nervous system
Publications
Selected peer-reviewed publications (15 from 137 peer-reviewed publications)
Ferretti F, Gisslen M, Cinque P, Price RW. Cerebrospinal Fluid HIV Escape from Antiretroviral Therapy.
3/6/15
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
Page 1 / 3
Curriculum vitae
Paola Cinque
Curr HIV/AIDS Rep 2015, in press.
Ferretti F, Gianotti N, Lazzarin A, Cinque P. Central nervous system HIV infection in "less-drug
regimen" antiretroviral therapy simplification strategies. Semin Neurol 2014;34:78-88 PMID: 24715491
Sospedra M, Schippling S, Yousef S, Jelcic I, Bofill-Mas S, Planas R, Stellmann JP, Demina V, Cinque
P, Garcea R, Croughs T, Girones R, Martin R. Treating progressive multifocal leukoencephalopathy
with interleukin 7 and vaccination with JC virus capsid protein VP1. Clin Infect Dis. 2014 Dec
1;59(11):1588-92. doi: 10.1093/cid/ciu682
Clifford DB, Nath A, Cinque P, Brew BJ, Zivadinov R, Gorelik L, Zhao Z, Duda P. A study of mefloquine
treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML
outcomes. J Neurovirol. 2013 Aug;19(4):351-8. doi: 10.1007/s13365-013-0173-y
Peluso MJ, Ferretti F, Peterson J, Lee E, Fuchs D, Boschini A, Gisslén M, Angoff N, Price RW, Cinque
P, Spudich S. Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in
patients on antiretroviral therapy with well controlled plasma viral load. AIDS 2012;26:1765-74 PMCID:
PMC3881435
Schouten J, Cinque P, Gisslen M, Reiss P, Portegies P. HIV-1 infection and cognitive impairment in the
cART era: a review. AIDS 2011;25:561-75. Review PMID: 21160410
Gorelik, L., Reid, C., Testa, M., Brickelmaier, M., Bossolasco, S., Pazzi, A., Bestetti, A., Carmillo, P.,
Wilson, E., McAuliffe, M., Tonkin, C., Carulli, J.P., Lugovskoy, A., Lazzarin, A., Sunyaev, S., Simon, K.,
Cinque, P. Progressive multifocal leukoencephalopathy (PML) development is associated with
mutations in JC virus capsid protein VP1 that change its receptor specificity. J Infect Dis
2011;204:103-14. PMCID: PMC3307153
Reid CE, Li H, Sur G, Carmillo P, Bushnell S, Tizard R, McAuliffe M, Tonkin C, Simon K, Goelz S,
Cinque P, Gorelik L, Carulli JP. Sequencing and analysis of JC virus DNA from natalizumab-treated
PML patients.
J Infect Dis. 2011 Jul 15;204(2):237-44. doi: 10.1093/infdis/jir256.
Cinque, P., Koralnik, I.J., Gerevini, S., Miro, J.M., Price, R.W. Progressive multifocal
leukoencephalopathy in HIV-1 infection. Lancet Infect Dis 2009;9:625-36. PMCID: PMC2919371
De Luca A, Ammassari A, Pezzotti P, Cinque P, Gasnault J, Berenguer J, Di Giambenedetto S,
Cingolani A, Taoufik Y, Miralles P, Marra CM, Antinori A; Gesida 9/99, IRINA, ACTG 363 Study
Groups. Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive
multifocal leukoencephalopathy: a multicohort analysis. AIDS. 2008 Sep 12;22(14):1759-67. doi:
10.1097/QAD.0b013e32830a5043.
Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG,
Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M,
Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE. Updated research nosology for
HIV-associated neurocognitive disorders. Neurology 2007;69:1789-99
Cinque P, Brew BJ, Gisslen M, Hagberg L, Price RW. Cerebrospinal fluid markers in central nervous
system HIV infection and AIDS dementia complex. Handb Clin Neurol 2007;85:261-300
Bossolasco S, Calori G, Moretti F, Boschini A, Bertelli D, Mena M, Gerevini S, Bestetti A, Pedale R,
Sala S, Sala S, Lazzarin A, Cinque P. Prognostic significance of JC virus DNA levels in cerebrospinal
fluid of patients with HIV-associated progressive multifocal leukoencephalopathy. Clin Infect Dis
2005;40:738-44.
Cinque, P., Bestetti, A., Marenzi, R., Sala, S., Gisslen, M., Hagberg, L., Price, R.W. Cerebrospinal fluid
interferon-γ-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection. J Neuroimmunol 2005;168:15463.
Cinque P, Nebuloni M, Santovito ML, et al. The urokinase receptor is overexpressed in the AIDS
dementia complex and other neurological manifestations. Ann Neurol 2004;55:687-9
D'Arminio Monforte, A., Cinque, P., Mocroft, A., Goebel, F.-D., Antunes, F., Katlama, C., Justesen,
U.S., Vella, S., Kirk, O., Lundgren, J. Changing Incidence of Central Nervous System Diseases in the
EuroSIDA Cohort. Ann Neurol 2004;55:320-8.
Cinque P, Casari S, Bertelli D. Progressive multifocal leukoencephalopathy, HIV, and highly active
antiretroviral therapy. N Engl J Med. 1998 Sep 17;339(12):848-9.
Cinque, P., Vago, L., Mengozzi, M. et al. Elevated cerebrospinal fluid levels of monocyte chemotactic
protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS 1998;12:1327-32
Cinque, P., Vago, L., Ceresa, D., Mainini, F., Terreni, M.R., Vagani, A., Torri, W., Bossolasco, S.,
Lazzarin, A. Cerebrospinal fluid HIV-1 RNA levels: Correlation with HIV encephalitis. AIDS
1998;12:389-94.
Weber T, Trebst C, Frye S, Cinque P, Vago L, Sindic CJ, Schulz-Schaeffer WJ, Kretzschmar HA,
3/6/15
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
Page 2 / 3
Curriculum vitae
Paola Cinque
Enzensberger W, Hunsmann G, Lüke W. Analysis of the systemic and intrathecal humoral immune
response in progressive multifocal leukoencephalopathy. J Infect Dis. 1997 Jul;176(1):250-4.
Cinque P, Vago L, Dahl H, Brytting M, Terreni MR, Fornara C, Racca S, Castagna A, D'Arminio
Monforte A, Wahren B, Lazzarin A, Linde A. Polymerase chain reaction on cerebrospinal fluid for
diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected
patients. AIDS 1996;10:951-8.
Cinque P, Brytting M, Vago L, Castagna A, Parravicini C, Zanchetta N, D'Arminio Monforte A, Wahren
B, Lazzarin A, Linde A. Epstein-Barr virus DNA in cerebrospinal fluid of patients with AIDS-related
primary lymphoma of the central nervous system. Lancet 1993;342:398-401.
Projects
Ongoing Research Support
Funding Agency: Gilead Fellowship Program PI: P.Cinque 09/01/2013-08/30/2015
The potential role of the central nervous system as HIV reservoir: insights from the study of
cerebrospinal fluid and tissues samples from long-term art-treated suppressed patients
Role: PI
Funding Agency: PML Consortium. PI: P. Cinque 01/14/2015-01/13/2017
CD4+ T-cell responses against wild-type and mutated JCV-VP1 peptides.
Role: PI
Completed Research Support (past two years)
Funding Agency: Biogen Idec. PI: P. Cinque 2010-2013
Assessment of the biological significance of the JC virus non coding control region (NCCR)
rearrangements in an in vitro model of JCV replication.
Role: PI
Funding Agency: Biogen Idec. PI: P. Cinque 2010-2013
Assessment of the JCV-specific CD8+ T-cell response in PML, natalizumab and rituximab-treated
patients by IFN-gamma Elispot using novel peptides.
Role: PI
Memberships
Italian Society of Infectious and Tropical Diseases (SIMIT)
European AIDS Cinical Society (EACS)
Other Relevant Information
Awards and Other Professional Activities:
1994: G.B. Rossi Award (ANLAIDS, Italy);
1997: Murex Award (European Society for Clinical Virology)
2005: Panel member of NIMH/NINDS Update on Diagnostic Definitions of HIV-Associated Dementia
and Minor Cognitive Motor Disorder in the Era of HAART
2005: Subcommittee on Biomarkers, Panel member, “NIMH/NINDS Update on Diagnostic Definitions
of HIV-Associated Dementia and Minor Cognitive Motor Disorder in the Era of HAART.
2008-current: Member of the DHHS Panel on Progressive Multifocal Leukoencephalopathy (PML),
Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and
Adolescents
2010-onwards: Panel Coordinator, Neurocognitive Disorders in HIV Infection, Italian Guidelines for the
Prevention and Treatment of HIV infection
2010-onwards: Scientific Committee member, Italian Cohort of Antiretroviral Naïve Patients - ICONA
2011-onwards: Panel Coordinator, Neurocognitive Impairment, European AIDS Society Clinical
Society (EACS) co-morbidities guidelines
2014: Panel Member, Opportunistic Infections, European AIDS Society Clinical Society (EACS) comorbidities guidelines
3/6/15
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
Page 3 / 3