CURRICULUM VITAE PERSONAL DATA Name Birth date Present role Home address Work address Telephone E-mail Nationality Diego Di Lorenzo 20/06/1955 Biologist (Director of the Laboratory of Biotechnology) Via Giacomo Soldi 48, 25082 Brescia, Italy. Laboratorio di Chimica Clinica/Biotecnologie Civic Hospital of Brescia P.le Spedali Civili 1, 25123 Brescia, Italy. +39 030 2191039 (home); +39 030 3996805-808 (work); +39 030 307251 (fax); +39 335 5923653 (cell. phone) [email protected] Italian SCHOOLS • Date • Institute • Date • Title obtained • Institute • Date • Institute • Date • Title obtained • Institute • Date • Title Obtained • Institute • Date • Title Obtained • Institute 1980 Internship Laboratory of Hormonology and Toxicology Spedali Civili di Brescia, Italy 1982 Degree in Biological Sciences University of Milan, Italy. February – May 1986 Institute of Genetics, National Research Council (CNR), Pavia, Italy. 1987 Master (6 months) in: Techniques and Topics in Molecular Biology. Berkeley University (UCB), California, USA. 2000 Specialization in Biochemistry and Chemical Chemistry University of Brescia, Italy 2014 International Master Level II in Nutrition and Dietetics. University of Ancona, Italy 1 PERSONAL PROFESSIONAL EXPERIENCE • Date • Institute • Date • Institute • Date • Institute • Date • Institute • Date • Institute • Date • Institute • Date • Istituto/Ente 1980 – 1986 Laboratory of Hormonology and Toxicology, University of Brescia, Italy. February 1983 – May 1983 PostDoctoral Fellow at the Ludwig Institute for Cancer Research, Bern, Switzerland. March 1986 – March 1987 PostDoctoral Fellow at the “John Muir Cancer Institute”, Walnut Creek, California, USA. Marzo 1987 – Marzo 1989 PostDoctoral Fellow at the Pharmacology Department, Stanford University, Stanford, USA. Marzo 1989 – Novembre 1992 Research Fellow at the ITBA- Istituto di Tecnologie Biomediche Avanzate di Brescia (CNR), Spedali Civili di Brescia, Italy 1992 - 2005 Senior biologist and responsible for the Molecular Diagnostic Laboratory at the Laboratory of Biotechnology, Ospedale Civile di Brescia, Italy. 2005 - Today Director of the Molecular Diagnostic Laboratory at the Laboratory of Biotechnology, Ospedale Civile di Brescia, Italy. PRESENT POSITION Position C2 at the Laboratory of Biotechnology, Civic Hospital of Brescia, Italy FUNDED PROJECTS DEVELOPED • Date • Project • Title 1989 – 1995 Progetto Finalizzato Ingegneria Genetica, CNR, Italy. Hormonal regulation of expression of the alpha-1-acid glycoprotein gene in rat and human hepatoma cell lines and in transgenic animals. • Date • Project • Title 1992 Progetto bilaterale Italia/NATO. CNR (92.01019.CT04.) Steroid hormone regulation of the growth, differentiation and syntesis of membrane proteins in breast cancer cells. 1992 – 1994 EUROPEAN COMMISSION. Bridge Projects - Animal Cell Technology Preparation of cell lines expressing high levels of steroid receptors in a modulatable fashion. • Date • Project • Title • Date • Project • Title • Date From 1990 Fondi dell’Università degli Studi di Brescia, Italy (40% e 60%). Struttura e regolazione della espressione dei geni eucarioti: Regolazione dell’Alfa-1-Glicoproteina Acida. 1994 2 • Project • Title Research contract NIRECO-Università di Brescia Brescia. Studio dell’effetto degli ormoni steroidei sull’interazione di fattori nucleari coinvolti nell’espressione di geni di linfochine a seguito di attivazione linfocitaria. • Date • Project • Title 1995 – 1997 EUROPEAN COMMISSION. Human Capital and Mobility Program. Role of transcription factors of the C/EBP family in gene regulation, cell differentiation and normal function in mouse development. • Date • Project • Title 1998 – 2001 EUROPEAN COMMISSION FP3, BIOMED-2. Transgenic mice as innovative system for the screening and the pharmacokinetic analysis of new molecules active through nuclear receptors. (Network:Brescia-Milan-Friburg-Berlin). • Date • Project • Title 2002 – 2006 EUROPEAN COMMISSION FP4, Environment and Health. Development and implementation of new in vivo and in vitro systems for the characterization of endocrine disruptors”. (Acronimo: EDERA). • Date • Project • Title 2001 – 2004 FIRB: Programma Strategico Post-genoma. PNR 2001-2003 (FIRB art.8) D.M. 199 Ric del marzo 2001. Anno 2001 - Protocollo: RBNEO157EH. Identificazione ed analisi funzionale delle alterazioni molecolari e geniche che caratterizzano i tumori della mammella ormono-responsivi. 2002 – 2004 • Date • Project • Title National Institute of Health (ISS). Analisi del rischio degli alimenti da contaminazioni ambientali (ARACNA). • Date • Project 2006 – 2010 EUROPEAN COMMISSION. FP6, STREP. Life sciences, genomics and biotechnology for health. (Acronimo : EXERA) Development of 3D in vitro models of estrogen-reporter mouse tissues for the pharmaco-toxicological analysis of estrogen receptors-interacting compounds (ER-ICs). • Title • Date • Project Title 2012 – 2015 EUROPEAN COMMISSION. EUROTRANSBIO. (Acronimo: ERIC) Innovative 2D and 3D cell culture systems for the pharmacological analysis of hormonal moleculaes. 3 MEMBER EDITORIAL BOARDS • Date From 2008 Member of the Editorial Advisory Board Members del “The Open Toxicology Journal” http://www.benthamscience.com/open/totoxij/ Betham Sciences • Date From 2016 Member of the Editorial Advisory Board of the“International Journal of Nutritional Sciences” http://austinpublishinggroup.com/nutritional-sciences/ Austin Publishing Group • Date 2004 Medaglia della società Irlandese di Tossicologia come riconoscimento all’attività scientifica svolta nell’anno 2004. AWARDS EXPERT EVALUATOR (CONSULTANT) AT THE EU COMMISSION • Date 2001 (3-7, December) 2002 (11-15, March) 2002 (10-14, June) 2006 (16-17, October) Contract n°: QLEV-2001-15438 Contract n°: QLEV-2002-22668 Contract n°: QLEV-2002-23700 Contract n°: FP6-2004-FOOD-513991-PIONEER) D. ACTIVITIES AT THE EU COMMISSION • Date 2003 Membro del Technical Working Panel su “INTEGRATED MONITORING” alla Commissione Europea Commissione Europea, Directorate B - Quality of Life Health, Nature & Biodiversity, ENV.B4. D. SCIENTIFIC ACTIVITY • Publications • Referee Author of 70 articles on indexed international journals Referee of tens of papers for international journals E. LANGUAGE MOTHER LANGUAGE Italian OTHER LANGUAGES English • Reading • Writing • Talking Excellent Very good Very good 4