Group Leader
Maria d’Erme, associate professor
Dept. of Biochemical Sciences
Sapienza University
00185 Roma
phone:+39 0649910923
fax: +39 064440062
e-mail: [email protected]
Group members
Luciana Mosca, researcher
e-mail: [email protected]
Italo Tempera, post-doc fellow
e-mail: [email protected]
Key words (max 5)
Neurodegeneration, CTCF, diabetes, epigenetics
Research projects
Interaction of “chromatin insulators” and PARP:
- Cross-talk between CTCF and PARP in Epstein Barr virus and tyroid cancer cell lines
Type 2 diabetes:
- Poly(ADP-ribose)polymerase activity and type 2 diabetes.
- Proteomic analysis to identify protein changes and post-translation-modifications in type
2 diabetes
Neurodegeneration:
- New insights into Beta-Amyloid induced PARP activation
- Role of poly(ADP-ribosylation) on overexpression and cellular localization of misfolded
proteins
Collaborations
Paul Lieberman
Wistar Inst. Univ. of Philadelpia USA
Elena Mattia
Dept. of Public Health Sciences, Sapienza Univ. Roma
Antonello Mai
Dept. of Chemistry and Technology of drug Sapienza Univ. Roma
Gouliang Yang
Univ. of Drexel- Philadelphia USA
Publications (last 5 years)
1 - Tempera I, Buchetti B, Lococo E, Gradini R, Mastronardi A, Mascellino MT, Sale P, Mosca L,
d'Erme M, Lenti L. (2008) GD3 nuclear localization after apoptosis induction in HUT-78 cells.
Biochem Biophys Res Commun. 368:495-500
2 - Mosca L, Tempera I, Lendaro E, Di Francesco L, d'Erme M. Characterization of catecholthioether-induced apoptosis in human SH-SY5Y neuroblastoma cells. (2008) J Neurosci Res.
86:954-60.
3 - Mattiussi S, Tempera I, Matusali G, Mearini G, Lenti L, Fratarcangeli S, Mosca
L, D'Erme M, Mattia E. (2007) Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr
Virus lytic cycle progression. Infect Agent Cancer. 11;2:18.
4 - Mosca L, Lendaro E, d'Erme M, Marcellini S, Moretti S, Rosei MA. 5-S-Cysteinyl-dopamine
effect on the human dopaminergic neuroblastoma cell line SH-SY5Y. (2006) Neurochem Int.
49:262-9.
5 -Tempera I, Cipriani R, Campagna G, Mancini P, Gatti A, Guidobaldi L, Pantellini F, Mandosi E,
Sensi M, Quesada P, Mario UD, D'Erme M, Morano S. Poly(ADP-ribose)polymerase activity is
reduced in circulating mononuclear cells from type 2 diabetic patients. (2005) J Cell Physiol.
205:387-92.
