Presentazione - Istituto Veneto di Scienze Lettere ed Arti

IMMAGINI
NASCOSTE
NEL
GENOMA
(e musiche)
SERGIO BARLATI
03 – DICEMBRE - 2013
IL DNA E’ CONTENUTO NEI CROMOSOMI ED E’ COSTITUITO DA 4
MOLECOLE, IDENTIFICATE DALLE LETTERE A-T-C-G, LEGATE IN
SEQUENZE RAPPRESENTATE DA MILIONI DI LETTERE
CROMOSOMI
IN CELLULA FEMMINILE
CARIOTIPO:
RICOSTRUZIONE DELLE
COPPIE DI CREMOSOMI
2003 COMPLETATO IL SEQUENZIAMENTO
DEL GENOMA UMANO
HGSC : DNA da molti donatori
CELERA: DNA da 5 soggetti
IN GRIGIO LE ZONE NON SEQUENZIATE
2007:
IL PRIMO GENOMA PERSONALE
di Craig Venter - Fondatore di Celera
(in 4 anni, al costo:75 milioni EURO)
2013:
GENOMA PERSONALE
(in pochi giorni, al costo: 5-6000 EURO)
(BGI- ILLUMINA)
SB
Genoma umano
Formato da 2 x 3,000,000,000 basi di
DNA, localizzati in 22 paia di cromosomi
(CHR) oltre al CHR X e CHR Y (24 CHR)
Codifica per 20,318 geni codificanti proteine
e per 22,560 “geni” codificanti RNA.
Solo circa 1% del Genoma è di sequenze che
codificano proteine e circa il 2%,
complessivamente, che codifica “geni”.
Circa 2,900,000,000 basi sono presenti nel
Genoma con altre funzioni (note solo in
parte).
CHR
Geni
Numero
basi
1
2.968
245.203.898
2
2.288
243.315.028
3
2.032
199.411.731
4
1.297
191.610.523
5
1.643
180.967.295
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
1.963
1.443
1.127
1.299
1.440
2.093
1.652
748
1.098
1.122
1.098
1.576
766
1.454
927
303
288
1.184
231
170.740.541
158.431.299
145.908.738
134.505.819
135.480.874
134.978.784
133.464.434
114.151.656
105.311.216
100.114.055
89.995.999
81.691.216
77.753.510
63.790.860
63.644.868
46.976.537
49.476.972
152.634.166
50.961.097
IMPORTANZA DEL DNA NON CODIFICANTE
E’ più variabile, fra le diverse specie di vertebrati, rispetto al DNA
codificante (es. Uomo/pesce palla).
Vi sono sequenze non codificanti mantenute conservate in diverse
specie di Vertebrati anche se non hanno associata una funzione nota.
Il DNA non codificante è meno sensibile alle mutazioni di singole
basi ma è conservato nelle singole specie animali e le caratterizza.
Possibile rilevanza del DNA non codificante nel definire specie
diverse e nella programmazione associata allo sviluppo embrionale e
al differenziamento cellulare.
Si sa ancora troppo poco del DNA non codificante che è uno dei più
importanti temi di studio.
Necessarie anche nuove strategie di analisi …..idee…
CATENA DI DNA
SEQUENZA DI DNA
3 MILIARDI DI NUCLETIDI:
200 VOLUMI DI 1000 PAGINE
CTAACCCTAACCCTAACCCTAACCCTAACCCTAACCCTCTGAAAGTGGACCTATCAGCAGGATGTGGGTGGGAGCAGATTAGAGAATAAAAGCAGACTGCCTGAGCCAGCAGTGGCAACCCAATGGGGTCCCTTTCCATAC
TGTGGAAGCTTCGTTCTTTCACTCTTTGCAATAAATCTTGCTATTGCTCACTCTTTGGGTCCACACTGCCTTTATGAGCTGTGACACTCACCGCAAAGGTCTGCAGCTTCACTCCTGAGCCAGTGAGACCACAACCCCACCA
GAAAGAAGAAACTCAGAACACATCTGAACATCAGAAGAAACAAACTCCGGACGCGCCACCTTTAAGAACTGTAACACTCACCGCGAGGTTCCGCGTCTTCATTCTTGAAGTCAGTGAGACCAAGAACCCACCAATTCCAGA
CACACTAGGACCCTGAGACAACCCCTAGAAGAGCACCTGGTTGATAACCCAGTTCCCATCTGGGATTTAGGGGACCTGGACAGCCCGGAAAATGAGCTCCTCATCTCTAACCCAGTTCCCCTGTGGGGATTTAGGGGACC
AGGGACAGCCCGTTGCATGAGCCCCTGGACTCTAACCCAGTTCCCTTCTGGAATTTAGGGGCCCTGGGACAGCCCTGTACATGAGCTCCTGGTCTGTAACACAGTTCCCCTGTGGGGATTTAGGGACTTGGGCCTTCTGT
CTTTGGGATCTACTCTCTATGGGCCACACAGATATGTCTTCCAACTTCCCTACACAGGGGGGACTTCAAAGAGTGCCTTGAGCTGATCTGGTGATTGCTTTTTTGTACTGTTATTTATCTTATTCTTTTCATTGTGAGGTACT
GATGCAAACACTTTGTACGAAAAGGTCTTTCTCATCTCGGGAGTCCCCGTCTATTTGTCCCGGTCCCTGTTAACCCAGTCCCCGACAGGAGCCCCTTCTGCACCTTGAGCTCTCACCACTCACCGTCCATCCAGCCCCAGCT
CTGCCTGCAACCCACCCATCCCTGGGACTCGGGCCTCCCCTCTCTAGTGGTCTGGTCATCAGGCCAGGGGCACGTGGAAGAAGCTATCGTGGCAAAGGGAGCAGTCATATCCCCAAAATCTGTGGTTGGTTTACCACCAC
CATGGAAACCCCAGGGTGGGACTCTAGTTTCAGGTTGGAGCTGAGCCCTGTCGGGAATGAGCTTTCCCCAGCTATGGCTTCTTGGGGCCCCTGTGCCCTGAGCTGTGTCTCCCAGCATCGGGTCCCCACCATGCATATGG
CCCACTCAGGCACAGTGCCGCGATGGCTGCATGCGTGAGGGGGGCCTGGGCCCAGGGCTGGGAGTCCTTTGTGTCTCATGGCCATGATTGTCCTTCCGAGTATGATATGGTGGCCAATTTCTTTTATTCTGTCGTTCAGA
GTGAGTAAATGATGTAGAGTTCATGCAGAAAAAAATACAACAAAAACCAAGGGAACATAGAATTGGAAAACGCGTCACAGCAATGAGTTAAATAGGTAACAAATTTCATCATTTGAAGAAAGACTTAGAGTGCCAAAAGTG
CCTCTTAAGTCTCCTTTAAAAAGTAGCAAAATTCATCCCTGAAGAAGCATCTTGGCCTTTTTCATGTACTCAGAGTGCTGGTGAAGAACAAAGATTGCTGAAACATTATGTACCTAACAGCGTTACAGGGTGTAGATAACAC
ACTGGAAAACCTGGTCGTTACAGTGGACATATTCCAGGAAGTCCTTGCCTGAGGTTTTCCAAGTTATGGAATTGCTTGAGATTGGAAGAGGCGATGGAGGGTACAACTGTAATGCCCAACCTCATTTTTGCTAACCCTGTT
TTTAGACTCTCCCTTTCCTTCAATCACCTAGCCTTCTTTCCACCTGAAAGGACTCTCCCTTAACTGAGAGAACCGGACAGACTCCATCTTGGCTCTTTCACTGGCAGCCCCTTCCTCAAAGACTTAACTCGTGCAAGCTGACT
CCCAGGACATCCGAGAATGCAATTAACTGACAACCTACTGTGGCGAGCTACATCCGCAGTCCCCAGGAATTCGTCCGATTGATAACGCCCAATTACCCGCGTCTATCACCTTGTAATAGTCTTAAAGCACCTGCACCTGGA
ACTGTTTACTTTCCTGTAACCATTTATCCTTTTAACATTTTGCCTGATTTACTTATGTAAAATTCTTTTAACTAGACCGCCACTCCCCTTTCTAAACAAAAGTATAAAAGAAAATCTAGCCCCTTCTTTGGGACTGAGACAATT
TTGAGGTTAACGCAGGGTGCCTGTAATCCTAAGGGAGGAGACCGCCACTTCTGCTGCCCTTCCCTTCCCCACACCCCCTTCTCTAGTTTATGAAACAGGGAAAAAGGGAGAAAGCAAAAAGATAAAAAAAACAGAAGTAA
GATAAATAGCTAGACGACCTTGGCAGCACCACCCGGCACTGGTGGTTAAAATAATAATAATAATAATATTAACCCCTGACCTAAACTACTTGTGTTATCTGTAAATTCCAGACACTGTATGAGGAAGCCCTGCAAAACTTTC
TGTTCTGTTATCTGATGCGTGTAGCCCCCAGTCACGTTCCGATGCTTGCTCGATCTATCACGACCCTTTCAAGTGAACCCCTTAGAGTCGTAAACCCTTAAAAGGGCCAGGAATTTCGTTTTCGGGGAGCTCGGCTCTTCAG
GCCCAAGTAAACCTGCCGTATCTCACCTGAGACCAACCCCCAACTACAAAACTCAACCTGGAATTTTCCCAGGACCAAACCCATCTATATTCTGTAACCCGAAACCTCAAAGCCTAACCCTAACCCTAACCCCTACAGTTGA
GGTCCCCCCGCCCCTGTGGTTCCAGCTCAAGACAACCTGCCCCTCCGTGGGTTTGCAGGCCCTCTGGTGGGGGTGGGAGCTGGGGGCCACATACAGCTCTCTGAGCTTAAGCCATTTTCTTCCTTCATTCCTTCCTTCCTC
CCTCCCTTCCCTTCCTTCCTCCCTCCCTCCCTCCTTCCCTCCCTCCCTTTTTTTTTTCAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCACAGCTGACTGCAGCCTCGGACTCCCAGGCTCAAGTTATCT
TCCCTCCTCAGCCTCCAGAGTAGGTGGGACTACAGGAGTGTGCCATCGCACCCAGCGAATTTCTTAATTTTTATTTTGTAGAGATGAGGCCTCTCGATATTGTCCAGGCTTGGAAGTAGTTCTTGAAATTCAAGAGGATCTT
GAAGTTCTGACCTCCTGTCAATATCCCTTCCCCTCACCTTGACCCTCCCATTCTGCCCCACCTGTCAGGATCACAAGGACCCCCAGATCAGCAGATGGGAACCGGACCAAAAAGAGAAATAGTGCTGTCCCGCCCATAAGT
ACCACCCCCAGACTCCCTGCTCCACCCTCTGGACCACAGGGAGGCCCCATGCTCCATCCCTGAAAACCACCCCCAGACCCCCTGCTCCTCCCCACGGGACCGCCCCCAGATCCACTGTTCCTGTCCTCCGGACCACACCGG
ACAGCTCCTTCCCTCGGCGCCATCCCCAGACCCCAGCTCCTCCCCTCAGGATCATCCCCAGACCCCCGCTCCTCCCATCAGGACCGCCCCCAGAACCCCCTGCTCCTCCCCACAGGACCACCCCCAGACCCCCGCTCCTCC
CCTAAGGACCACCCACAGACCCCCACGCTTCCCCTCGGGACCACCCCCAGACCCCCGCTCCTCCCCTCAGGACCACCCCCAGATCCACTGTTCCTGTCCTCCGGACCACACCAGACAGCTCCTTCCCTCGGCGCCATCCCC
AGACCCCCACGCTTCCCCTCGGGACCACCCCCAGACCCCCGCTCCTGCCCTCGGGACCACGCCCAGACCCCCTGCTCCTCCCCACGAAACCACGCCCAGTAACCCCCCTCTTCTCCCCTCAGGACCACCCCCAGACCCCCG
CTCCTCCCCTGGGAACCACCCCCAGACCCCCTGCTCCTCCCCACGAAACCACCCCCAGACTCCCTGCTCCTGTCCTCCGGACCACGCGACTGCTCCTTCCCTCAGCGCCACCCCCAGACTGCCGCTCCTCCTGTCGGGACC
CCCTGAGGCTTTCTCCACCCGGAGTGCGGGGTAGGGAGCAGACGGAGAGTGACGGAGGGTGACGGAGAGTGACGAAAGTAGACGATGTCTGACGGAGAAGAGCCGAGCGGAGCTGAAGGGCGGCGGAGAGTGACGGA
AAGTGGCGAGAATTGACGGAAAGTGACGGGGACTGACGGACAGTGACGAAGAGTCACGAAATTTATCAGAGGGCGACAAAGAGGAAAGCGAAATGGTGAGATGCAGCCGGCCGAGCCTAATCGGAGATGACGGAAAGT
GACGGAGAGGAACGAGGAGTAAAGAGGGGTGACGAAAAGAGCCGAAGCTGGTGGAGGCGAAGAACTGAGTGAGGGAAGATAGCCGAGATTAGCGGGTGGGCTGCAGCCGGGGCAGTCGCCCGAATGGGCGGGACCCC
ACGGAGTTAGCGAGAGGATGCGAACAGCGGCCAGCCGGGCAGCACGCGAGCGAGGGAGGGCGTGGAGGGCCGTGGGTCCGCCTGCACTGAGGCAGGCATGCGTGGCACCGAGGTGACCCGGGTGGGAGGTGCACCG
CCGCCCCCTGGCAGTCTCTCCGCGGAGCCCAAGCCCGTCTTCTCCGCCCCTTTGCAGACCTCGGCGCCCAGCCTGGCCCCTGACGCCCACCCGCGGCCCCACCCAGCGCCCGGGCCCACGAGGCCGAGGAGCGGCGGAG
ACTAACGGCCCCTGGACCCCAGGCAGCACATGGCCCAGAGCATCCCAGCCCAGTGGAGGGCGGCACATGGCGGGAGGGCGGGAGTCCGTGTCCACTCATGGCCGGGGAGGGGAGGGCAAGTTCTGGTGGCTGGGGAG
GCCTAGAGCATCACAGCCCAGTGGAGGGCTGCACATGGCAGGGGAGGGGAGAGCAAGAGTGTGCGGGCGAGGGAGGAGAGGGCAAGACTGCGTGTCCGCTCCAGTCTCTCTTCCTCATCTTATAAAGCCACGAGTCCC
ATGACTGGGGACCCAACCTAATAACATTATCTAATCCTAATTGCCTCCCAAAGGCCATATCTCCAATCAGGACATGAATTCGGGGATTAAATTGCCAACACATGGCTGGGCGCGATGGCTTGTGCTTTTTTTTTTTTTTTTTT
TGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCAC
GCCCAGGTAATTTTTTTTTTTTTTTTTTTGTATTTCTTTGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCATCTCGGTCTCCCAAAGTGCTAGGATTGCAGGCCTGAGC
CACCGCACCCAGCTGCCTTGTGCTTTTAATCCCAGCACTTTCAGAGGCCAAGGCAGGCGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTAATACAAATACAAAAAAAAAACAA
AAAACGTTAGCCAGGAATGAGGCCCGGTGCTTGTAATCCTAAGGAAGGAGACCACCACTCCTCCTGCTGCCCTTCCCTTCCCCACACCGCTTCCTTAGTTTATAAAACAGGGAAAAAGGGAGAAAGCAAAAAGCTTAAAAA
AAAAAAAAAAAAAACAGAAGTAAGATAAATAGCTAGATGATCTTGGCAGCACCACCCGACCCTGGTGGTTAAAATAATAATAATAATAATATTAACCCCTGACCTAAACTACTTGTGTTATCTGTAAATTCCAGACACTGTA
TGAGGAAGCCCTGCAAAACTTTCTGTTCTGTTATCTGATGCGTGTAGCCCCCAGTCACGTTCCCCATGCTTCCTCGATCTATCACAACCCTTTCACGTAAACCCCTTAGAGTTGTAAACCCTTAAAAGGGCCAGGAATTTCG
TTTTCGGGGAGCTTGGCTCTTCAGGCGCAAGTGTGCCGATGCTCCTGGCAGAGTAAAGCCCTTCCTTCTTTAACCCAGTGTCTGAGGAATTTTGTCTGCGGCTTGTCCTGCCACAATGCCAGCTACCAGGAGGCTGAGGT
GTGAGAATCGCTCGAACCTGGGAGGCAGAGGTTGCAGCGAGCCGAGATCCCACGATTGCACTCCAGCCTGGGTGATAGATGACAGAGCAAGACACCATGTCAAAAAGAAAAGAAAAAAAATTGCCAACACATGAAATCTG
GAGAACACATTCAAGCAATAGCACCATATAAATCTGTACATACCTTGCAAACACTGTAAACCTGCCGCATCTCACCTGAGACCAACCCCCAACCGCAAAACCCAGACCTGGAATTTTCCCAGGACCAAACCCATCTATATTC
TGTAACCCGAAATCTCAAAGCCTAACCCTAACCCTAACCCCGACAGTTCAGGTCCCCCCGTCCCCGTAGCTCCAGCTCAAGACAACCTGCCCCTCCGTGGGTTTGCAGGCCCTTTGGTGGGGGTGGGAGCTGGGGGCCAC
ACACAGCTCTCTGAGCTTAAGCCATTTCCTTCCTTCCTTCATTCCTTCCTTCCTCCCTCCCTCCCTCCTTCCCTCCCTCCCTTTTTTTTTTCAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCACAGCTG
ACTGCAGCCTCGGACTCCCAAGCTCAAGCGATCTTCCCGCCTCAGCCTCCAGAGTAGGTGGGACTACAGGAGTGTGCCATCGCACGTGGCGAATTTCTTAATTTTTATTTTGTAGAGATGAGGCCTCCCGATATTGTCCAG
GCTTGGAAGTAGTTCTTGAAATTCAAGAGGATCTGGAAGTTCTGGTCTCCTGTCAATATCCCTTTCTAAGATGAAATGTAGAATCCTCTAATCACCCCAGGATACCTTTTCCAGCTATATTACCCTTTCCTTTCAGCCGACTA
GAGTGGAAGCTCAGCAAAGAACGGATCTATGCCTGCACACAGGCAGCTTTGAACTCACTGAGATCTATAGAAGAATTTTTTAAAATTTGCCAGAATGAAAAAGAAGTATCCTCCAGTGAGCCTCAAGGACAGCCAGGGAA
GGCAGCTACTGGGACCTGCCACTGGCCAGGATTGAGAGAGTCTGAGGTGTCCATTCTCCTATGGATGGGTCACACATCAGAACTGAACCACAAACCCTTTCCTGCTCCCTTGGGACCAGGCTGCCACTCCTTCCTTCCCCT
CACCTTGACCCTCCCATTCGGCCCCACCTGTCAGGATCACAAGGACCCCCAGATCAGCAGATGGGAACCGGACCAAAAAGAGAAATAGCGCTGTCCCGCCCAAAAGTACCAACCCCAGACCCCCTGCTCCACCCTCCGAA
CCACAGGGAGACCCCATGCTCCACCCCTGAAAACCACATGCAGACCCCCGCTCCTCCTCTTAGGGCCATCCCCAGACCCCCCCTCCTACCCACGGGACCACACCCAGAACCCCCAGCTCCTCCCCTCGGGACCACCCCAGA
CCCCCGCTCCTCCCCTCGGGACCACCCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCTGCTCCTCCTCTTAGGACCATCCCCAGACCCCCCCTCCTACC
CACGGGACCACACCCAGAACCCCCAGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCC
CCAGACCCCCTGCTCCTCCTCTTAGGACCATCCCCAGACCCCCCCTCCTACCCACGGGACCACACCCAGAACCCCCAGCTCCTCCCCTCGGGACCACCCCCAGACCCCCTGCTCCTCCTCTTAGGACCACCCCAGACCCCC
GCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCCGACCCCCTGCTCCTCCTCTTAGGACCATCCCCAGACCCCCCCTCCTACCCACGGG
ACCACACCCAGAACCCCCAGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCCAGAC
CCCCTGCTCCTCCTCTTAGGACCATCCCCAGACCCCCCCTCCTACCCACGGGACCACACCCAGAACCCCCAGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCC
CCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCCAGAACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCTCCTCCCCTCGGGACCACCC
CCAGACCCCCTGCTCCTCCTCTTAGGACCATCCCCAGACCCCCCCTCCTACCCACGGGACCACCCCCAGACCCCCCGCTCCTCCCCTCGGGACCACCTCAGACCCCCGCTCCTCCCCTCGGGACCACCCCAGACCCCCGCT
CCTCCCCTCGGGACCACCCCAGACCCCCTGCTCCCATTTTCCAGACCACACCAGACGGCTTCTTCCCTCGGCACCACCCCCAGACTGCCGCTCCTCCTATCGGGACCTCCTCGGGGCCATCTCCAGACCCTCCCCCCGCTC
CACCCCTCGGGTCCCTCTCGGGACCACCCTCAGACCCCCGCTCCTTCCCTCGGGATCACCTCGAGACCTCCCGCTCACCACCATCATTCAGGCCGGGTAGTGGGGAGAGGCCTCTCAGGAGGGACCAGGCCACCCTCCCA
chrX - da 57621731 a 57630804: 9073 bp
SVILUPPATO UN
SOFTWARE
PER TRASFORMARE
IL GENOMA
IN
IMMAGINI
chrX - da 57621731 a 58597343
975.613 bp
A:VERDE
T: ROSSO
C: BLEU
G: NERO
INTERO GENOMA IN CIRCA 3000 PAGINE (SCHERMATE PC)
SYMBOL COLOUR
DNA COLOUR
* Brevetto Europeo dell’Università di Brescia
N.° 06115244.3.
GENE: SMCY (41.00bp)
CROMOSOMA Y
DA: 20.200.000
A: 21.000.000
= 800.000bp
CERCANDO NEL GENOMA
(NON CODIFICANTE)
E ABBINANDO DIVERSI COLORI
SI POSSONO OTTENERE
IMMAGINI CHE,
OLTRE AD AVERE
UN POSSIBILE VALORE
«ESTETICO» (ASTRATTO) ,
HANNO ASSOCIATA
UN’INFORMAZIONE.
SEGUONO ALCUNI ESEMPI
CHR2:
DA
1.977.753
A
1.980.000
bps
CHR2:
DA
91.682.006
A
91.744.222
bps
CHR3:
DA
90.523.300
A
90.585.025
bps
CHR4:
DA
48.928.063
A
48.990.105
bps
DA
CHR 2
DA
CHR17
DA
CHR19
DA
CHRs:
XeY
SEQUENZE
ALTAMENTE
VARIABILI
COINVOLTE NELLA
PLASTICITA’
DEL DNA
DNA
DINAMICI
LE IMMAGINE OTTENUTE POSSONO
ESSERE STAMPATE SU LASTRE DI
VETRO PER OTTENERE QUELLI CHE
HO DEFINITO:
“VETRI PARLANTI”
IMMAGINI ASTRATTE CHE HANNO
ASSOCIATA UN’INFORMAZIONE
(SPESSO «FUNZIONE» DA DEFINIRE)
I VETRI PARLANTI
I “VETRI PARLANTI” PRENDONO VITA DALLA LUCE DEL SOLE
(CON IL SOLE IL DNA VIVE)
“LE ALI DEL DNA”
OPERA VINCITRICE, PER
IL TEMA PITTURA, DEL I°
CONCORSO D’ARTE
DELL’Ist.Sup.Sanità.
“ IL VOLO DI PEGASO”
2008/09
dal Cromosoma X
dalla posizione:
61.598.923 a 61.729.14
Sergio Barlati
FOTO DEL VETRO
I° FESTIVAL RECYCLART
MOSTRA “VETRI PARLANTI” - CANONICA DEL DUOMO
CASTIGLIONE DELLE STIVIERE (MN) 2009
http://www.recyclart.it/2009/home.php?section=arte&sub=dna
II° FESTIVAL RECYCLART
“LE PORTE DELLA CONOSCENZA” - SALA ESPOSIZIONI
CASTIGLIONE DELLE STIVIERE (MN) 2010
(TRASFORMAZIONE DI TESTI IN IMMAGINI – VEDI PIEGHEVOLI)
IL DECALOGO
DEL CERVELLO
LA «TRINITA’»
BIOLOGICA
IL DECALOGO
DEL DNA
http://www.recyclart.it/home.php?section=arte&sub=dna
PROGETTO PER EXPO 2015
LA «CATTEDRALE» DEL DNA
PROPONENTE: Sergio Barlati
UNIVERSITA’ DI BRESCIA
IL PROGETTO HA AVUTO:
BASSA PRIORITA’
DALLE IMMAGINI
ALLA MUSICA
AD OGNI LETTERA O SIMBOLO DA
SEQUENZE DI: DNA, PROTEINE O TESTO,
SI ABBINA UNA NOTA SPECIFICA CON
CARATTERISTICHE SCELTE A PIACERE:
STRUMENTI, OTTAVE, DURATA
SEQUENZA DI DNA CHE CODIFICA PER IL
GENE DEL “GLUTAMATE RECEPTOR 1”
ATGCAGCACATTTTTGCCTTCTTCTGCACCGGTTTCCTAGGCGCGGTAGTAGGTGCCAATTTCCCCAACAATATCCAGATCGGGGGAT
TATTTCCAAACCAGCAGTCACAGGAACATGCTGCTTTTAGATTTGCTTTGTCGCAACTCACAGAGCCCCCGAAGCTGCTCCCCCAGAT
TGATATTGTGAACATCAGCGACAGCTTTGAGATGACCTATAGATTCTGTTCCCAGTTCTCCAAAGGAGTCTATGCCATCTTTGGGTTTT
ATGAACGTAGGACTGTCAACATGCTGACCTCCTTTTGTGGGGCCCTCCACGTCTGCTTCATTACGCCGAGCTTTCCCGTTGATACATCC
AATCAGTTTGTCCTTCAGCTGCGCCCTGAACTGCAGGATGCCCTCATCAGCATCATTGACCATTACAAGTGGCAGAAATTTGTCTACAT
TTATGATGCCGACCGGGGCTTATCCGTCCTGCAGAAAGTCCTGGATACAGCTGCTGAGAAGAACTGGCAGGTGACAGCAGTCAACATT
TTGACAACCACAGAGGAGGGATACCGGATGCTCTTTCAGGACCTGGAGAAGAAAAAGGAGCGGCTGGTGGTGGTGGACTGTGAATCA
GAACGCCTCAATGCTATCTTGGGCCAGATTATAAAGCTAGAGAAGAATGGCATCGGCTACCACTACATTCTTGCAAATCTGGGCTTCA
TGGACATTGACTTAAACAAATTCAAGGAGAGTGGCGCCAATGTGACAGGTTTCCAGCTGGTGAACTACACAGACACTATTCCGGCCAA
GATCATGCAGCAGTGGAAGAATAGTGATGCTCGAGACCACACACGGGTGGACTGGAAGAGACCCAAGTACACCTCTGCGCTCACCTA
CGATGGGGTGAAGGTGATGGCTGAGGCTTTCCAGAGCCTGCGGAGGCAGAGAATTGATATATCTCGCCGGGGGAATGCTGGGGATTG
TCTGGCTAACCCAGCTGTTCCCTGGGGCCAAGGGATCGACATCCAGAGAGCTCTGCAGCAGGTGCGATTTGAAGGTTTAACAGGAAA
CGTGCAGTTTAATGAGAAAGGACGCCGGACCAACTACACGCTCCACGTGATTGAAATGAAACATGACGGCATCCGAAAGATTGGTTAC
TGGAATGAAGATGATAAGTTTGTCCCTGCAGCCACCGATGCCCAAGCTGGGGGCGATAATTCAAGTGTTCAGAACAGAACATACATCG
TCACAACAATCCTAGAAGATCCTTATGTGATGCTCAAGAAGAACGCCAATCAGTTTGAGGGCAATGACCGTTACGAGGGCTACTGTGT
AGAGCTGGCGGCAGAGATTGCCAAGCACGTGGGCTACTCCTACCGTCTGGAGATTGTCAGTGATGGAAAATACGGAGCCCGAGACCC
TGACACGAAGGCCTGGAATGGCATGGTGGGAGAGCTGGTCTATGGAAGAGCAGATGTGGCTGTGGCTCCCTTAACTATCACTTTGGTC
CGGGAAGAAGTTATAGATTTCTCCAAACCATTTATGAGTTTGGGGATCTCCATCATGATTAAAAAACCACAGAAATCCAAGCCGGGTG
TCTTCTCCTTCCTTGATCCTTTGGCTTATGAGATTTGGATGTGCATTGTTTTTGCCTACATTGGAGTGAGTGTTGTCCTCTTCCTGGTCA
GCCGCTTCAGTCCCTATGAATGGCACAGTGAAGAGTTTGAGGAAGGACGGGACCAGACAACCAGTGACCAGTCCAATGAGTTTGGGA
TATTCAACAGTTTGTGGTTCTCCCTGGGAGCCTTCATGCAGCAAGGATGTGACATTTCTCCCAGGTCCCTGTCTGGTCGCATCGTTGGT
GGCGTCTGGTGGTTCTTCACCTTAATCATCATCTCCTCATATACAGCCAATCTGGCCGCCTTCCTGACCGTGGAGAGGATGGTGTCTC
CCATTGAGAGTGCAGAGGACCTAGCGAAGCAGACAGAAATTGCCTACGGGACGCTGGAAGCAGGATCTACTAAGGAGTTCTTCAGGA
GGTCTAAAATTGCTGTGTTTGAGAAGATGTGGACATACATGAAGTCAGCAGAGCCATCAGTTTTTGTGCGGACCACAGAGGAGGGGAT
GATTCGAGTGAGGAAATCCAAAGGCAAATATGCCTACCTCCTGGAGTCCACCATGAATGAGTACATTGAGCAGCGGAAACCCTGTGAC
ACCATGAAGGTGGGAGGTAACTTGGATTCCAAAGGCTATGGCATTGCAACACCCAAGGGGTCTGCCCTGAGAAATCCAGTAAACCTG
GCAGTGTTAAAACTGAACGAGCAGGGGCTTTTGGACAAATTGAAAAACAAATGGTGGTACGACAAGGGCGAGTGCGGCAGCGGGGGA
GGTGATTCCAAGGACAAGACAAGCGCTCTGAGCCTCAGCAATGTGGCAGGCGTGTTCTACATCCTGATCGGAGGACTTGGACTAGCC
ATGCTGGTTGCCTTAATCGAGTTCTGCTACAAATCCCGTAGTGAATCCAAGCGGATGAAGGGTTTTTGTTTGATCCCACAGCAATCCAT
CAACGAAGCCATACGGACATCGACCCTCCCCCGCAACAGCGGGGCAGGAGCCAGCAGCGGCGGCAGTGGAGAGAATGGTCGGGTGG
TCAGCCATGACTTCCCCAAGTCCATGCAATCGATTCCTTGCATGAGCCACAGTTCAGGGATGCCCTTGGGAGCCACGGGATTGTAA
CODICE UTILIZZATO: 2 BASI del DNA (BP)
(CORRISPONDENZE BP - NOTE (FAST)
BP
NOTE
AA
AC
AG
AT
CA
CC
CG
CT
GA
GC
GG
GT
TC
TG
TT
:DO
: RE
: MI
: FA
: SOL
: LA
: SI
: DO
: RE
: MI
: FA
: SOL
: SI
: DO
: DO
OTT. TEMPO
: 4 : 1/16
: 4 : 1/16
: 4 : 1/8
: 4 : 1/8
: 4 : 1/16
: 4 : 1/16
: 4 : 1/8
: 4 : 1/8
: 4 : 1/16
: 4 : 1/16
: 4 : 1/8
: 4 : 1/8
: 4 : 1/16
: 4 : 1/8
: 4 : 1/8
TAIKO DRUM
CODICE UTILIZZATO: 2 BASI del DNA (BP)
(CORRISPONDENZE BP - NOTE (SLOW)
BP
NOTE
OTT. TEMPO
AA
AC
AG
AT
CA
CC
CG
CT
GA
GC
GG
GT
TA
TC
TG
TT
: DO
: RE
: MI
: FA
: SOL
: LA
: SI
: DO
: RE
: MI
: FA
: SOL
: LA
: SI
: DO
: DO
:2
:2
:3
:3
:3
:3
:2
:2
:3
:3
:3
:3
:2
:3
:3
:2
: 1/4
: 1/4
: 1/8
: 1/8
: 1/4
: 1/4
: 1/8
: 1/4
: 1/4
: 1/4
: 1/8
: 1/4
: 1/4
: 1/4
: 1/8
: 1/4
LEAD3 (Organo - Calliope)
Un grazie al Prof. Danieli
per l’invito
e
un grazie sentito a Tutti Voi.
Un ricordo a Frederick SANGER, Padre
dell’Era Genomica, morto
a 95 anni, il 19 Novembre scorso.
«UN APPLAUSO X SANGER»
GRAZIE
Sergio Barlati