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Endoscopic Retrograde Cholangiopancreatography
Endoscopic retrograde cholangiopancreatography (ERCP) is performed by gastroenterologists
or surgeons to evaluate the bile duct, pancreatic duct, and ampulla.
Bile and pancreatic enzymes are released into the small bowel to assist digestion. Bile flows from the liver, is stored in the gallbladder, then
flows through the common bile duct. Similarly, pancreatic enzymes
flow from the pancreas through the pancreatic duct. The ampulla is
the confluence of the biliary and pancreatic ducts. Both of these ducts
can become blocked or narrowed by stones, tumors, or inflammation.
Endoscopic Retrograde Cholangiopancreatography (ERCP)
ERCP is a procedure used to investigate abnormalities of the bile duct,
pancreatic duct, and ampulla using an endoscope.
Common
bile duct
Endoscope
Stomach
LIVER
How ERCP Is Used
DUODENUM
Duodenum
e
Pancreas
Flo
wo
f bil
The ERCP procedure is used to investigate abnormalities of the common bile duct, pancreatic ducts, and ampulla. It can also be used to
perform certain therapeutic interventions. The procedure is performed with a specialized endoscope, a long, maneuverable tube
with a camera that passes through the mouth, esophagus, and stomach to work within the duodenum. A miniaturized video camera on the
tip of the endoscope allows the doctor to see a greatly magnified view
of the inside of the gastrointestinal tract on a video monitor. Images
of the bile and pancreatic ducts are made by injecting a special liquid
(a radiocontrast agent) into the ducts while taking x-rays. Specialized
instruments are passed through the endoscope to perform biopsies,
retrievestones,dilateanarrowing,orplacea stent (ashorthollowtube
that allows bile or pancreatic fluid to flow past a narrowing).
Endoscope features
Camera
allows physician to see
inside duodenum, ampulla,
and ends of ducts
Probe/instruments
perform biopsies, clear
stones, dilate a narrowing,
or place a stent
Pa
nc
re
Ampulla
a ti
Pancreatic
duct
c enzy m e
s
Endoscopic view
Side Effects
Probe
Most patients tolerate ERCP without significant complications. Minor
complications are associated with anesthesia and occur in 5% to 7% of
patients. More significant risks include pancreatitis (inflammation of
the pancreas) in 3% to 5% of patients (as high as 15% in high-risk patients), bleeding, infection, and, rarely, perforation of the intestines.
What to Expect
Prior to ERCP, you may be asked to abstain from eating and drinking for at least 6 hours. The procedure is performed using either deep
sedation (a form of anesthesia in which a patient is allowed to
breathe on his or her own) or general anesthesia (with a breathing
tube) depending on the patient and the complexity of the procedure required. Patients undergoing the procedure are typically comfortable without significant pain during or afterward and generally
do not remember the procedure at all. Often, ERCP is performed in
an outpatient setting.
Authors: Ioana Baiu, MD, MPH; Brendan Visser, MD
Conflict of Interest Disclosures: The authors have completed and submitted the
ICMJE Form for Disclosure of Potential Conflicts of Interest. No disclosures were
reported.
Sources: NIH state-of-the-science statement on endoscopic retrograde
cholangiopancreatography (ERCP) for diagnosis and therapy. NIH Consens State Sci
Statements. 2002;19(1):1-26.
Wandling MW, Hungness ES, Pavey ES, et al. Nationwide assessment of trends in
choledocholithiasis management in the United States from 1998 to 2013. JAMA Surg.
2016;151(12):1125-1130.
2050
Patients are placed under deep sedation or
general anesthesia during the procedure.
FOR MORE INFORMATION
• American College of Gastroenterology
patients.gi.org/topics/ercp-a-patients-guide
The JAMA Patient Page is a public service of JAMA. The information and
recommendations appearing on this page are appropriate in most instances, but they
are not a substitute for medical diagnosis. For specific information concerning your
personal medical condition, JAMA suggests that you consult your physician. This page
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JAMA November 20, 2018 Volume 320, Number 19 (Reprinted)
© 2018 American Medical Association. All rights reserved.
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